2'-Deoxycytidine As A Potential Biomarker For Detection Of Heptocellular Carcinoma
Ahmed, W., Moneer, M., Abo-Shady, M., Mansour, H., Abd-El-Wahab, N., Yoshioka, M., El-Merzabani, M. (2005). 2'-Deoxycytidine As A Potential Biomarker For Detection Of Heptocellular Carcinoma. EKB Journal Management System, 21(1), 191-201. doi: 10.21608/ejhm.2005.18060
Wafaa Abdallah Ahmed; Manar Moneer; Maha M. Abo-Shady; Heba Hosny Mansour; Nahed Abd-El-Wahab; Masanori Yoshioka; Mahmoud El-Merzabani. "2'-Deoxycytidine As A Potential Biomarker For Detection Of Heptocellular Carcinoma". EKB Journal Management System, 21, 1, 2005, 191-201. doi: 10.21608/ejhm.2005.18060
Ahmed, W., Moneer, M., Abo-Shady, M., Mansour, H., Abd-El-Wahab, N., Yoshioka, M., El-Merzabani, M. (2005). '2'-Deoxycytidine As A Potential Biomarker For Detection Of Heptocellular Carcinoma', EKB Journal Management System, 21(1), pp. 191-201. doi: 10.21608/ejhm.2005.18060
Ahmed, W., Moneer, M., Abo-Shady, M., Mansour, H., Abd-El-Wahab, N., Yoshioka, M., El-Merzabani, M. 2'-Deoxycytidine As A Potential Biomarker For Detection Of Heptocellular Carcinoma. EKB Journal Management System, 2005; 21(1): 191-201. doi: 10.21608/ejhm.2005.18060

2'-Deoxycytidine As A Potential Biomarker For Detection Of Heptocellular Carcinoma

The Egyptian Journal of Hospital Medicine
Article 16, Volume 21, Issue 1, October 2005, Page 191-201  XML PDF (393.69 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2005.18060
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Authors
Wafaa Abdallah Ahmed1; Manar Moneer2; Maha M. Abo-Shady3; Heba Hosny Mansour4; Nahed Abd-El-Wahab5; Masanori Yoshioka6; Mahmoud El-Merzabani7
1Department of Cancer Biology
2Department of Epidemiology and Biostatistics
3Microbiology & Immunology department, Faculty of pharmacy (girls), Al-Azhar University
4Health Radiation Research Department, National Center for Radiation Research and Technology, (NCRRT)
5Department of Clinical Pathology National Cancer Institute, Cairo University, Cairo, Egyp
6Department of Analytical Chemistry, Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan.
7Department of Cancer Biology (*Chemotherapy Unit)
Abstract
Background: 2'-deoxycytidine (Dcyd) is one of four major nucleosides found in the different normal body fluids due to dissolution of dead cells, and is increase in the presence of malignancy. Previous studies proved that it can be used as a marker for bladder cancer and acute lymphoblastic leukemia. The aim of this study is to assess 2'Dcyd as a possible biological marker in hepatocellular carcinoma (HCC).
Methods: Four groups were evaluated for the level 2'-Dcyd as well as alpha-fetoprotein (AFP); a control group (n = 20), 20 cases of chronic liver diseases (CLD), 20 cases of hepatitis C (HCV) 60 cases of HCC.
Results: In the patients with HCC, 2'-Dcyd serum level was 8-fold higher than normal level. It was 3-fold higher in HCV group. A mild increase was noted in patients with chronic liver diseases. Levels ≥ 0.14 of 2'-Dcyd had a sensitivity of 93% and specificity of 90% for diagnosis of HCC. It also recorded a sensitivity and specificity of 90% for diagnosis of HCV. Conclusions: For diagnosis of HCC, 2'-Dcyd is no better than AFP, as it is elevated in viral hepatitis C. A combination of AFP and 2'-Dcyd could provide broader information in diagnosis and treatment decision.
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