Cytokine Storm in COVID-19 Patients: Association between cytokines and disease severity | ||||
Zagazig University Medical Journal | ||||
Article 752, Volume 27, Issue 6, November 2021, Page 1640-1653 PDF (1.18 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zumj.2021.76794.2237 | ||||
View on SCiNiTO | ||||
Authors | ||||
Walaa M. Sarhan 1; Sally M Shalaby 2; Nahla Zidan3; Abeer Elhawary4; Nagwan Ismail5; Vishruti Makani6; Hanim Magdy Abd elnour7 | ||||
1Medical Biochemistry & Molecular Biology department, Faculty of Medicine, Zagazig University | ||||
2Medical Biochemistry Department-Faculty of Medicine- Zagazig University-Egypt | ||||
3Clinical Pathology Department, Faculty of Medicine, Zagazig University | ||||
4Chest Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||||
5Chest Department, Faculty of Medicine, Zagazig University | ||||
6Process Development Scientist, KBI Biopharma, Durham, NC, US | ||||
7medical biochmestry and molecular biology department, faculty of medicine, Zagazig univerisity, Zagazig, Egypt | ||||
Abstract | ||||
Objectives: To determine the cytokine storm profile in patients with COVID-19 infection in relation to the disease severity. Methods: Serum levels of TNF-α, IFN-γ, IL-6 and IL-1β were measured by ELISA method and IL-1RII, TNFR1 and TNFR2 gene expression in peripheral blood mononuclear cells (PBMCs) were done using real time polymerase chain reaction (PCR) method in a total of 203 COVID-19 patients. The 1st group included 52 COVID-19 severe cases, the 2nd comprised 104 moderate cases and the 47 mild cases lied in the 3rd group. Results: There was a significant association between degree of COVID-19 severity and IL6, TNF-α & IFN-γ serum levels (p < /p> | ||||
Keywords | ||||
COVID-19; interferon-γ (IFN-γ); Tumor Necrotizing Factor α (TNF-α); Interleukin 6 (IL-6); Cytokine receptors | ||||
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