Interaction of sodium nitrite and sunset yellow and its effect on some biochemical parameters in young albino rats | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 14, Volume 19, Issue 1, April 2005, Page 156-167 PDF (359.19 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2005.18118 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Eman G.E. Helal1; Mervat Abdel-Rahman2 | ||||
| 1Zoology Department, Faculty of Science, Al-Azhar University (Girls) | ||||
| 2Clinical Pathology Lab., Student Hospital, Cairo University, Giza | ||||
| Abstract | ||||
| Children usually eat and drink food containing both food preservatives, as sodium nitrite and food colourants, as sunset yellow (S.S.Y) at the same time. The mixture of the two agents at the limited dose of each was found to be lethal. 1/10th of this dose was used daily for 30 days. Animals were divided into three groups. The first served as a control, while the second was orally administered a mixture of sodium nitrite (NaNO3) and S.S.Y. The third received garlic in addition to the above mixture. Half of the animals from each group were decapitated after 30 days of treatment, while the other half was left for another 15 days for recovery. Investigation of the mixture of sod.nitrite and S.S.Y significantly decreases protein and albumin. Significant increases were observed in cholesterol, gamma-glutamyltranspeptidase (GGT), alkaline phosphatase (AP), lactate dehydrogenase (LDH) and creatine phosphokinase (CPK). No change was observed for Total protein, Triglyceride, aspartate aminotransferase (AST), alanine aminotransferase(ALT) and acid phosphatase (AcP) recorded. A complete recovery from the abnormalities of most biochemical parameters was observed after the recovery period or when garlic was administered. This draws attention to the dangers of interactions of such preservatives and colourants. The present study showed that even the permitted doses of colourants and food preservatives may be harmful. And illustrate that usage of garlic may ameliorate some of the expected hazards of food additions. | ||||
| Keywords | ||||
| Garlic; NaNO3; sunset yellow | ||||
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