Association between Neutrophil-To-Lymphocyte and Platelet-To-Lymphocyte Ratios with Chronic Allograft Nephropathy | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 97, Volume 84, Issue 1, July 2021, Page 2231-2236 PDF (709.59 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2021.181215 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Walid Ahmed Ragab Abdelhamid* | ||||
| Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||||
| Abstract | ||||
| Background: In several diseases, both neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are reliable indicators of chronic inflammation. Endothelial dysfunction is widely distributed in renal transplant patients and is caused by inflammation and can lead to the malfunction of the graft. Objective: To detect the correlations of NLR and PLR with chronic allograft nephropathy (CAN) in recipients of kidney transplants and determine the cutoff values for the prediction of CAN. Patients and Methods: 68 kidney transplant recipients shared in the study between January 2017 and December 2019. They were two groups. Group 1 (44 subjects) had estimated glomerular filtration rate (eGFR) ≥ 60 ml/m/1.73 m2 and group 2 (24 subjects) had eGFR less than 60 ml/m/1.73 m2. Results: The two groups had similar age and sex distributions. eGFR was shown to be adversely linked to NLR and PLR. The optimal cutoff level of NLR for predicting chronic allograft nephropathy was ≥1.58 and the optimal cutoff level of PLR was ≥109.13. Conclusion: Significant correlations were detected between kidney function tests and each of NLR and PLR. PLR is a more sensitive inflammatory marker to predict chronic allograft nephropathy than NLR with a sensitivity of 83.33 % versus 66.67 %. | ||||
| Keywords | ||||
| Glomerular Filtration Rate; Graft Rejection; Inflammation; Kidney Transplantation | ||||
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