Protective Effect Of Ascorbic Acid On Cisplatin Genotoxicity In Male Mice Bone Marrow Cells | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 3, Volume 18, Issue 1, January 2005, Page 16-22 PDF (275.27 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2005.18138 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Nada, H.A. Al- Twaty | ||||
| Department of Biology, King Abdelaziz Universiy | ||||
| Abstract | ||||
| Cisplatin (cis-diamminedichloroplatinum II) is an effective antitumor agent with a wide spectrum of activity against varies solid tumors, but it has serious side effects on nontumour cells. Cisplatin produces intra- and interstrand DNA cross-linking effects and chromosomal aberrations in mammalian cells. Vitamin C (ascorbic acid) is an antioxidant that can scavenge free radicals and protect cellular macromolecules, including DNA, from oxidative damage induced by different agents. Pretreatment administration of ascorbic acid on cisplatin induced chromosome aberrations has been determined in bone marrow cells of Swiss albino mice. Results showed that cisplatin (7.5 & 10mg/kg bw)IP injection to male mice induced significant increase in the frequencies of chromosomal aberrations. The results of pre-treatment with ascorbic acid (66mg/kg bw) showed a significant decrease in the number of chromosomal aberrations induced with cisplatin tested doses. Ascorbic acid did not exhibit any clastogenic effect in male mice bone marrow cells. We concluded that ascorbic acid has a protective role against the genotoxicity induced by antitumor drug cisplatin. | ||||
| Keywords | ||||
| Cisplatin- Antioxidants- Ascorbic Acid-Chromosomal Aberration- genotoxicity; Bone Marrow Cells- Mice | ||||
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