Modifying effects of Soybean and Nigella Sativa against Experimental Hepato-carcinogenesis induced By Nitrosamine Precursor in Rats. (Histopathological and electron microscopically study)
Waer, H., EL Asser, A., Ibrahim, H., Khalifa, M., Elgendy, S., Magrabi, K. (2005). Modifying effects of Soybean and Nigella Sativa against Experimental Hepato-carcinogenesis induced By Nitrosamine Precursor in Rats. (Histopathological and electron microscopically study). EKB Journal Management System, 18(1), 88-115. doi: 10.21608/ejhm.2005.18146
Hanaa F. Waer; Abdel Baset EL Asser; Hamdy A. Ibrahim; Maher M. Khalifa; Saad M Elgendy; Khaled I. Magrabi. "Modifying effects of Soybean and Nigella Sativa against Experimental Hepato-carcinogenesis induced By Nitrosamine Precursor in Rats. (Histopathological and electron microscopically study)". EKB Journal Management System, 18, 1, 2005, 88-115. doi: 10.21608/ejhm.2005.18146
Waer, H., EL Asser, A., Ibrahim, H., Khalifa, M., Elgendy, S., Magrabi, K. (2005). 'Modifying effects of Soybean and Nigella Sativa against Experimental Hepato-carcinogenesis induced By Nitrosamine Precursor in Rats. (Histopathological and electron microscopically study)', EKB Journal Management System, 18(1), pp. 88-115. doi: 10.21608/ejhm.2005.18146
Waer, H., EL Asser, A., Ibrahim, H., Khalifa, M., Elgendy, S., Magrabi, K. Modifying effects of Soybean and Nigella Sativa against Experimental Hepato-carcinogenesis induced By Nitrosamine Precursor in Rats. (Histopathological and electron microscopically study). EKB Journal Management System, 2005; 18(1): 88-115. doi: 10.21608/ejhm.2005.18146

Modifying effects of Soybean and Nigella Sativa against Experimental Hepato-carcinogenesis induced By Nitrosamine Precursor in Rats. (Histopathological and electron microscopically study)

The Egyptian Journal of Hospital Medicine
Article 11, Volume 18, Issue 1, January 2005, Page 88-115  XML PDF (1.98 MB)
Document Type: Original Article
DOI: 10.21608/ejhm.2005.18146
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Authors
Hanaa F. Waer1; Abdel Baset EL Asser2; Hamdy A. Ibrahim3; Maher M. Khalifa3; Saad M Elgendy2; Khaled I. Magrabi4
1National center for radiation research and Technology Atomic Energy Authority Cairo Egypt
2Cancer Biology Depart. Cancer Institute, Cairo University
3Zoology Depart. Faculty of science Mansora and Cairo University Cairo
4Zoology Depart Faculty of Medical Technology Alfatah University Libya
Abstract
Cancer has become an important topic in medicine since it is a major cause of death in the developing countries and it is now only secondary to that of myocardial infraction. Nitrosamines precursors are known to be carcinogenic to humans, in various organs at relatively low levels of exposure. It induces benign and malignant tumors especially liver tumors following its administration by various routes, including ingestion and inhalation. Humans may be exposed to Nitrosamines through the ingestion of food that contains it, such as cured meat products, and smoked fish. Other exposures to Nitrosamines may be from drinking contaminated water and from breathing cigarette smoke and contaminated ambient air. Individual are most likely to be exposed to Nitrosamines in occupational settings such as in the rubber, tannery, fish processing, dyes, and surfactant industries. The prevalence of liver tumors throughout the world makes in imperative to seek chemo preventive agents.
Vegetables, natural products of plant origin and numerous non-nutritive dietary constituents have been shown to play a salutary role in cancer chemoprevention. The present study aims to evaluate the chemo preventive efficacy of soy bean and Nigella sativa on hepato- carcinogenesis induced by dibuty1 nitrosamine (DEN).
It could be observed that both soy bean and Nigella sativa have a good effect of amelioration against liver hepatoma induced by nitrosamine. Soy bean more or less showed more prerogative effect than Nigella 9 and 12 months after administration.
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