Histological Assessment of Injectable Macro-porous Calcium Phosphate Cement (CPC) Versus Autogenous Bone Graft on Healing of Osseous Defect (Experimental Animal Study) | ||||
| Egyptian Dental Journal | ||||
| Article 7, Volume 67, Issue 3 - Serial Number 2, July 2021, Page 1953-1965 PDF (2.47 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/edj.2021.69779.1567 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Hosam eldin Mahmoud   1; Mostafa Ezz2; Hosam Sayur3; Hassan Abdel-Ghany 4
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| 1BDS, Msc., Faculty of Dentistry, Cairo University | ||||
| 2Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University | ||||
| 3Senior researcher, Animal Health Research Institute | ||||
| 4Associate Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cairo University | ||||
| Abstract | ||||
| Objective: The aim of this study is to evaluate histologically the healing potential of injectable macro-porous Calcium Phosphate Cement and autogenous bone. (Normal bone healing) on surgically induced bone defect on femur bone of rabbit. Materials and Methods: Twelve adult white male New Zealand rabbits were selected for this study. Rabbits were divided into two groups and the two groups according to a two evaluation periods divided into 2 subgroups. Rabbits were anesthetized with intramuscular anethesia, and two osseous defects had been created in the distal aspect of the femur bone.one of this defects injected by a grafting material (SI-HPMC CPC) and the other left empty as control (normal healing).Animal were sacrificed after two sacrifice dates and the femur bone excised for histological and statistical evaluation.esults: Rabbits from each group were sacrificed after 2 and 4 weeks. The femur bone containing the induced defect was dissected. Each femur bone was excised using hard tissue microtome. Each slice was then fixed in 10% neutral buffered formalin. The formalin-fixed bone samples were decalcified in 15% buffered formic acid solution and processed for routine histological examination using hematoxylin and eosin stain under light microscope.. Conclusion: According to our results in the present study, we can consider Si-HPMC CPC a viable alternative to the autogenous bone in the healing of osseous bone defects . In the present study, the new and simple method to prepare macroporous CPCs using Si-HPMC a foaming agent in connected syringe , result | ||||
| Keywords | ||||
| Macro-porous; Calcium Phosphate; Versus Autogenous Bone; bone defect | ||||
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