Systemic Correlative Study between Systemic Lupus Erythematosus, Osteoporoses And Dehydroepiandrosterone-S(DHEA-S)level In Premenoposal Egyptian Women
M, E., Helal, E., Elsayed, H., Gawish,, A. (2005). Systemic Correlative Study between Systemic Lupus Erythematosus, Osteoporoses And Dehydroepiandrosterone-S(DHEA-S)level In Premenoposal Egyptian Women. EKB Journal Management System, 18(1), 171-185. doi: 10.21608/ejhm.2005.18151
El Shafaey M; Eman G.E. Helal; Hala H. Elsayed; Abeer S.M. Gawish,. "Systemic Correlative Study between Systemic Lupus Erythematosus, Osteoporoses And Dehydroepiandrosterone-S(DHEA-S)level In Premenoposal Egyptian Women". EKB Journal Management System, 18, 1, 2005, 171-185. doi: 10.21608/ejhm.2005.18151
M, E., Helal, E., Elsayed, H., Gawish,, A. (2005). 'Systemic Correlative Study between Systemic Lupus Erythematosus, Osteoporoses And Dehydroepiandrosterone-S(DHEA-S)level In Premenoposal Egyptian Women', EKB Journal Management System, 18(1), pp. 171-185. doi: 10.21608/ejhm.2005.18151
M, E., Helal, E., Elsayed, H., Gawish,, A. Systemic Correlative Study between Systemic Lupus Erythematosus, Osteoporoses And Dehydroepiandrosterone-S(DHEA-S)level In Premenoposal Egyptian Women. EKB Journal Management System, 2005; 18(1): 171-185. doi: 10.21608/ejhm.2005.18151

Systemic Correlative Study between Systemic Lupus Erythematosus, Osteoporoses And Dehydroepiandrosterone-S(DHEA-S)level In Premenoposal Egyptian Women

The Egyptian Journal of Hospital Medicine
Article 16, Volume 18, Issue 1, January 2005, Page 171-185  XML PDF (358.44 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2005.18151
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Authors
El Shafaey M1; Eman G.E. Helal2; Hala H. Elsayed2; Abeer S.M. Gawish,3
1Internal Medicine Department. Faculty of Medicine, Ain Shams University
2Zoology Department. Faculty of science Al Azhar, University.
3Oral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of dentistry (girls) Al Azhar, University.
Abstract
Systemic Lupus Erythematosus (SLE) is an autoimmune disease commonly occurs in of childbearing age, with connective tissue inflammation particularly joints and causes characteristic rashes.
Subjects & Methods: the present study includs30 premenopausal females, they were divided into 3 groups. Group I consists o ten premenopausal females without SLE, Group II include ten premenopausal females had SLE,disease duration less than three years, Group III include ten premenopausal females had SLE,disease duration more than three years. Bone mineral density (BMD) in the heel of right foot by Achilles Express in all groups had been performed. Estimation of the serum level of Dehydroepiandrosterone Sulphate (DHEA-S) hormone and serum level of calcium, phosphorous ,sodium and potassium.
Results: the results of the present study showed that in group II the BMD was 10% with osteoporotic , 40% with osteopenic and 50% with normal BMD, group III the BMD was 10% with osteoporotic , 60% with osteopenic and 30% with normal BMD. The correlations were done between BMD and serum minerals calcium, phosphorous, sodium and potassium in SLE patients ( Group II&III). Statistically high significant increase was found among osteopenic versus control women. Moreover a significant increase of serum calcium and sodium while there was a significant decrease in serum DHEA-S, phosphorous and potassium.
Conclusions: There is a relationship between level of DHEA and the progression of SLE. Moreover there is relation between the decline in serum levels of DHEA-S and phosphorous , and the elevation of serum levels of calcium and the occurrence of osteoporosis in SLE.
Treatment with DHE is beneficial in controlling of the disease activity in LES patients.
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