SYNTHESIS AND ANTI-TUBERCULAR ACTIVITY OF SOME 1,2,4-TRIAZOLE DERIVATIVES
Eissa, A. (2002). SYNTHESIS AND ANTI-TUBERCULAR ACTIVITY OF SOME 1,2,4-TRIAZOLE DERIVATIVES. EKB Journal Management System, 11(1), 54-62. doi: 10.21608/zjps.2002.181560
Amal Eissa. "SYNTHESIS AND ANTI-TUBERCULAR ACTIVITY OF SOME 1,2,4-TRIAZOLE DERIVATIVES". EKB Journal Management System, 11, 1, 2002, 54-62. doi: 10.21608/zjps.2002.181560
Eissa, A. (2002). 'SYNTHESIS AND ANTI-TUBERCULAR ACTIVITY OF SOME 1,2,4-TRIAZOLE DERIVATIVES', EKB Journal Management System, 11(1), pp. 54-62. doi: 10.21608/zjps.2002.181560
Eissa, A. SYNTHESIS AND ANTI-TUBERCULAR ACTIVITY OF SOME 1,2,4-TRIAZOLE DERIVATIVES. EKB Journal Management System, 2002; 11(1): 54-62. doi: 10.21608/zjps.2002.181560

SYNTHESIS AND ANTI-TUBERCULAR ACTIVITY OF SOME 1,2,4-TRIAZOLE DERIVATIVES

Zagazig Journal of Pharmaceutical Sciences
Article 4, Volume 11, Issue 1, June 2002, Page 54-62  XML PDF (4.63 MB)
Document Type: Original Article
DOI: 10.21608/zjps.2002.181560
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Author
Amal Eissa email
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
Abstract
The synthesis of a number of bis-triazole derivatives starting from 2,2 -bis-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)diphenyl amine (I) was achieved . Reactions involving its two functional groups for structural diversity was performed. Thus reacting I in DMSO, in CS2/KOH, with acetic anhydride, chloroacetyl chloride, ethyl chloroacetate, epichlorohydrin, 2-chloro-5-nitropyridine, certain-2-chloro aromatic acids (alone or in presence of POCI3), variousα,ß-unsaturated ketones and different aldehydes afforded II-XII respectively. Compounds XIIb(a-h) were further cyclised in nitrobenzene to yield substituted bis-triazolothiadiazoles (XIIIa-h).
Compounds I-III, V, VIII, XI, XII, XIII were tested for their anti-tubercular activity. Compounds XIe and XIIIb were found to be active.
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