IBUPROFEN-QUERCETIN COMBINATION ASA NOVEL PHARMACEUTICAL COMPATIBLE SYSTEM
Abdel Mohsen, M., El-Badry, M., Soliman, O. (2001). IBUPROFEN-QUERCETIN COMBINATION ASA NOVEL PHARMACEUTICAL COMPATIBLE SYSTEM. EKB Journal Management System, 10(1), 29-33. doi: 10.21608/zjps.2001.181592
Mohamed Abdel Mohsen; Mahmoud El-Badry; Osama Soliman. "IBUPROFEN-QUERCETIN COMBINATION ASA NOVEL PHARMACEUTICAL COMPATIBLE SYSTEM". EKB Journal Management System, 10, 1, 2001, 29-33. doi: 10.21608/zjps.2001.181592
Abdel Mohsen, M., El-Badry, M., Soliman, O. (2001). 'IBUPROFEN-QUERCETIN COMBINATION ASA NOVEL PHARMACEUTICAL COMPATIBLE SYSTEM', EKB Journal Management System, 10(1), pp. 29-33. doi: 10.21608/zjps.2001.181592
Abdel Mohsen, M., El-Badry, M., Soliman, O. IBUPROFEN-QUERCETIN COMBINATION ASA NOVEL PHARMACEUTICAL COMPATIBLE SYSTEM. EKB Journal Management System, 2001; 10(1): 29-33. doi: 10.21608/zjps.2001.181592

IBUPROFEN-QUERCETIN COMBINATION ASA NOVEL PHARMACEUTICAL COMPATIBLE SYSTEM

Zagazig Journal of Pharmaceutical Sciences
Article 6, Volume 10, Issue 1, June 2001, Page 29-33  XML PDF (2.67 MB)
Document Type: Original Article
DOI: 10.21608/zjps.2001.181592
View on SCiNiTO View on SCiNiTO
Authors
Mohamed Abdel Mohsen email 1; Mahmoud El-Badry1; Osama Soliman2
1Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
2Department of Pharmaceutics Faculty of pharmacy. Mansoura University, Mansour. 35516. Egypt.
Abstract
The effect of oral administration of quercetin (QRT) (25 mg/kg) on an experimentally Ibuprofen- induced ulcer was studied in rats. The results of gross appearance and scanning electromicrographs of the mucous membrane and superficial cells of the stomach revealed that the quercetin reduced the damage of submucosal superficial cells. Differential scanning calorimetry, X-ray diffractometer, IR spectroscopy, solubility and partitioning studies elucidated the absence of any interaction between the two compounds and also the physical compatibility of ibuprofen (IP)-quercetin combination. It is concluded that ibuprofen and quercetin can be pharmaceutically co-formulated or co-administrated with the aim of reducing the gastrointestinal adverse effects of ibuprofen.
Statistics
Article View: 129
PDF Download: 35