UTILIZATION OF α-BROMOCYCLIC DIKETONES AS MICHAEL DONORS FOR THE SYNTHESIS OF COUMARIN ANALOGUES
El-Sawah, M., El-Bermawy, M., Abdel-Aal, E., Kadry, A., Al-Ashmawi, M. (2000). UTILIZATION OF α-BROMOCYCLIC DIKETONES AS MICHAEL DONORS FOR THE SYNTHESIS OF COUMARIN ANALOGUES. EKB Journal Management System, 9(2), 50-53. doi: 10.21608/zjps.2000.181616
Magdy El-Sawah; Mohamed El-Bermawy; Eatedal Abdel-Aal; Azza Kadry; Mohamed Al-Ashmawi. "UTILIZATION OF α-BROMOCYCLIC DIKETONES AS MICHAEL DONORS FOR THE SYNTHESIS OF COUMARIN ANALOGUES". EKB Journal Management System, 9, 2, 2000, 50-53. doi: 10.21608/zjps.2000.181616
El-Sawah, M., El-Bermawy, M., Abdel-Aal, E., Kadry, A., Al-Ashmawi, M. (2000). 'UTILIZATION OF α-BROMOCYCLIC DIKETONES AS MICHAEL DONORS FOR THE SYNTHESIS OF COUMARIN ANALOGUES', EKB Journal Management System, 9(2), pp. 50-53. doi: 10.21608/zjps.2000.181616
El-Sawah, M., El-Bermawy, M., Abdel-Aal, E., Kadry, A., Al-Ashmawi, M. UTILIZATION OF α-BROMOCYCLIC DIKETONES AS MICHAEL DONORS FOR THE SYNTHESIS OF COUMARIN ANALOGUES. EKB Journal Management System, 2000; 9(2): 50-53. doi: 10.21608/zjps.2000.181616

UTILIZATION OF α-BROMOCYCLIC DIKETONES AS MICHAEL DONORS FOR THE SYNTHESIS OF COUMARIN ANALOGUES

Zagazig Journal of Pharmaceutical Sciences
Article 8, Volume 9, Issue 2, December 2000, Page 50-53  XML PDF (1.6 MB)
Document Type: Original Article
DOI: 10.21608/zjps.2000.181616
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Authors
Magdy El-Sawah email 1; Mohamed El-Bermawy2; Eatedal Abdel-Aal3; Azza Kadry2; Mohamed Al-Ashmawi2
1Department of Pharmaceutical Org. Chem., Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
2Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
3Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Abstract
Coumarin nucleus is of biological importance. Anticoagulants which are very common contain coumarin moiety. Herein we describe a facile method to prepare this valuable nucleus. α-Bromocyclic diketones were used as Michael donors and each reacted with various substituted acrylonitriles, which behaved as Michael acceptors. Elimination of hydrobromic acid leads to the formation of the target compounds (17-30) in reasonable yields.
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