SYNTHESIS OF NEW NONCLASSICAL DIBENZODIAZEPINE DERIVATIVES AS POTENTIAL ANTIPSYCHOTIC AGENTS | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 2, Volume 9, Issue 1, June 2000, Page 9-16 PDF (3.25 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.2000.181618 | ||||
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| Authors | ||||
Osama El-Sabbagh  1; Abd-El Alim Abd-El Alim2
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| 1Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | ||||
| 2Depart. of Pharmacology, Faculty of Vet. Medicine , Zagazig University, Zagazig, Egypt. | ||||
| Abstract | ||||
| Two series of 8-chloro-2, 3, 4, 5,10,11-hexahydro-11-substituted-1H-dibenzob,e 1,4 diazepine-1-ones and their3,3- dimethyl analogs were prepared via internal Mannich reaction of 3-[(2- amino-4- chlorophenyl) amino] -2-cyclohexen-1-one and its 5,5-dimethyl analog, respectively, with different aldehydes at room temperature. The synthesized compounds were evaluated for their clozapine-like properties. The structures of the novel compounds were confirmed using elemental analyses and different spectroscopic methods. Pharmacological evaluation of some of the synthesized dibenzodiazepine derivatives revealed that compounds 4 and 17 (having 4-bromophenyl moiety) exhibited a high antipsychotic and sedative properties. | ||||
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