Synthesis and Spectral Study of Some New 4-substituted but-2-enolide Derivatives | ||||
| Egyptian Journal of Chemistry | ||||
| Article 26, Volume 64, Issue 12, December 2021, Page 7117-7122 PDF (464.8 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.80154.3957 | ||||
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| Authors | ||||
| Enas A. Altaee; Ammar H. Al-Sabawi | ||||
| Department of Chemistry, College of Science, University of Mosul, Mosul, IRAQ. | ||||
| Abstract | ||||
| A variety of some new substituted 4-amino-4-(bromomethyl)butolides (4a-g) have been synthesized by reactions 4-(Bromomethyl)but-2-enolide (2) with some (substituted benzylidene) benzene-1,4-diamine (3a-g) in the presence of absolute ethanol as a solvent to give the Michael addition products, while in the case of its reaction in the presence of pyridine as a solvent and base be added to the β- and - positions to be yield substituted 4-amino-4-(aminomethyl)butolides (5a-g). 4-(Bromomethyl)but-2-enolide (2) is prepared by the reaction 3,3-dimethylacrylic acid and N-bromo succinimide with benzoyl peroxide to give 3,3-Bis(bromomethyl)acrylic acid (1) and then the ring-closure reaction is carried out in basic media. All newly synthesized compounds were confirmed by spectral analysis and the corresponding reactions were monitored by TLC. | ||||
| Keywords | ||||
| Butenolides; Tetronic acid; Natural compounds; Schiff bases | ||||
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