Association of Islet Cell Antibody and Human Leucocyte Antigen DQB1 Alleles (0201/0302) in siblings of type 1 diabetes mellitus
Z.A., H., H.T., K., D.M, A., H.F, B., H.A., H. (2003). Association of Islet Cell Antibody and Human Leucocyte Antigen DQB1 Alleles (0201/0302) in siblings of type 1 diabetes mellitus. EKB Journal Management System, 12(1), 86-91. doi: 10.21608/ejhm.2003.18249
Hassan Z.A.; Kandeel H.T.; Abaza D.M; Bostamy H.F; Hssan H.A.. "Association of Islet Cell Antibody and Human Leucocyte Antigen DQB1 Alleles (0201/0302) in siblings of type 1 diabetes mellitus". EKB Journal Management System, 12, 1, 2003, 86-91. doi: 10.21608/ejhm.2003.18249
Z.A., H., H.T., K., D.M, A., H.F, B., H.A., H. (2003). 'Association of Islet Cell Antibody and Human Leucocyte Antigen DQB1 Alleles (0201/0302) in siblings of type 1 diabetes mellitus', EKB Journal Management System, 12(1), pp. 86-91. doi: 10.21608/ejhm.2003.18249
Z.A., H., H.T., K., D.M, A., H.F, B., H.A., H. Association of Islet Cell Antibody and Human Leucocyte Antigen DQB1 Alleles (0201/0302) in siblings of type 1 diabetes mellitus. EKB Journal Management System, 2003; 12(1): 86-91. doi: 10.21608/ejhm.2003.18249

Association of Islet Cell Antibody and Human Leucocyte Antigen DQB1 Alleles (0201/0302) in siblings of type 1 diabetes mellitus

The Egyptian Journal of Hospital Medicine
Article 10, Volume 12, Issue 1, April 2003, Page 86-91  XML PDF (264.14 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2003.18249
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Authors
Hassan Z.A.1; Kandeel H.T.2; Abaza D.M1; Bostamy H.F3; Hssan H.A.4
1Endocrinology Al Azhar University (girls)
2Endocrinology Al Azhar University (girls)
3Biochemistry Department – Cairo University
4General Medicine Departments – Al Azhar University (girls)
Abstract
Type 1 diabetes is most often associated with auto antibodies (AAbs) against beta cell antigens and high levels of HLA mediated genetic susceptibility. The purpose of this study was to identify at risk siblings of type1 diabetic patients at an early stage by screening for HLA– DQB1 alleles, which carry the high-risk genotype (DQB1 *0201 / 0302) and its associations with measured islet cell antibody (ICA). Twenty-five siblings of subjects with type 1 diabetes aged 4 – 13 yr, median age (8.4 ± 1.02) were studied. They were screened for ICA as well as HLA-DQB1 (0201 and 0302) alleles.
Results of the study showed that among the 25 siblings, 20% tested positive for ICA. HLA-DQB1 was detected in 16% of siblings. Allele DQB1 0201 presented higher frequency (48%) than DQB1 0302 (36%). Association of DQB1 0201 and / or 0302 with ICA positive cases was detected in 20% of cases, while frequency of DQB1 0201 and / or 0302 in ICA negative cases was detected in 48% of them.
In conclusion: - Our results showed that among siblings of type 1 diabetes HLA-DQB1 alleles associated with highest genetic susceptibility i.e. DQB1 0201 and / or 0302 were detected with high significance. Also HLA-DQB1 0201 is more frequently associated with ICA.
Initial screening by high risk DQB1 *0201/0302 with subsequent autoantibody testing is shown to be useful in the assessment of diabetes risk among siblings of subjects with type 1 diabetes.
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