Simple and Efficient Methods for the Synthesis of New Biologically Active Heterocycles
Elzamly, R., Zaky, H., Kandile, N. (2016). Simple and Efficient Methods for the Synthesis of New Biologically Active Heterocycles. EKB Journal Management System, 33(part1), 463-488. doi: 10.21608/jsrs.2016.18344
Rana A. Elzamly; Howida T. Zaky; nadia G. Kandile. "Simple and Efficient Methods for the Synthesis of New Biologically Active Heterocycles". EKB Journal Management System, 33, part1, 2016, 463-488. doi: 10.21608/jsrs.2016.18344
Elzamly, R., Zaky, H., Kandile, N. (2016). 'Simple and Efficient Methods for the Synthesis of New Biologically Active Heterocycles', EKB Journal Management System, 33(part1), pp. 463-488. doi: 10.21608/jsrs.2016.18344
Elzamly, R., Zaky, H., Kandile, N. Simple and Efficient Methods for the Synthesis of New Biologically Active Heterocycles. EKB Journal Management System, 2016; 33(part1): 463-488. doi: 10.21608/jsrs.2016.18344

Simple and Efficient Methods for the Synthesis of New Biologically Active Heterocycles

Journal of Scientific Research in Science
Article 37, Volume 33, part1, September 2016, Page 463-488  XML PDF (440.09 K)
Document Type: Original Article
DOI: 10.21608/jsrs.2016.18344
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Authors
Rana A. Elzamly email 1; Howida T. Zaky1; nadia G. Kandileorcid 2
1Department of Chemistry, Faculty of Women, Ain Shams University, Heliopolis,11757 Cairo, Egypt
2Chemistry Department Faculty of Women, Ain shams University,Heliopolis,Cairo,Egypt
Abstract
An efficient and simple synthesis of fused pyridazine derivatives has been developed. These fused pyridazines were used as key starting material for the preparation of new heterocyclic compounds. All the structures of the newly synthesized compounds were confirmed on the basis of FT-IR, 1H and 13CNMR, mass spectral techniques. Six of the new synthesized compounds (6f , 8c-f  and  8i) were selected and tested against a panel human tumor cell line HCT-116 (colon cancer) using Imatinib as standard drug. The cytotoxicity data of the tested compounds virus Imatinib in means of IC50 values were (6f, 8c-f and 8i) recorded as in (Figure I). The obtained data showed that the compounds 1-(3-(2-methoxyphenyl)-7-methoxyphenylisoxazolo[4,5-d]pyridazin-4-yl)hydrazine (8i) and 1-(3-(2-methoxyphenyl)-1-phenyl-7-methoxyphenyl-1H-pyrazolo[4,3-d]pyridazin-4-yl)hydrazine (8f) have high reactivity towards cell line HCT-116 (colon cancer) more than the standard drug Imatinib.  
 
Keywords
Heterocyclic compounds; Fused pyridazines; Tetrazolo; Sulfonamide; Colon cancer
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