The Role of Curcumin – Chitosan Nanoparticles in the Prevention and Treatment of liver Fibrosis in Mice | ||||
| Alfarama Journal of Basic & Applied Sciences | ||||
| Article 2, Volume 3, Issue 1, January 2022, Page 8-28 PDF (1.11 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajbas.2021.81964.1056 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohamed Negm  1; Neamat Ahmed2; Lamiaa Barakat1
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| 1Chemistry Department, Faculty of Science, Port Said University, Port Said, Egypt. | ||||
| 2National Centre for Radiation Research & Technology, Egyptian Atomic Authority, Cairo, Egypt. | ||||
| Abstract | ||||
| Background: Nanotechnology is one of the most rising up branch in modern science. A few years ago, natural product therapies play an important role in health care. The major application of nanotechnology in medicine was the development of nanoparticles as drug delivery system. The main advantages of using nanoparticles are large surface area, controlled particle size, site specific targeting, bioavailability, stability, biodegradable and controlled release of drug. Aim of the study: The present study had tested the potential of curcumin – chitosan nanoparticles as a great chance to apply the modern nanotechnology techniques in the prevention and treatment of liver fibrosis induced by carbon tetrachloride (CCl4) in male albino mice. Materials and Methods: 30g mice were divided into four groups; normal control, CCl4, prevention and treatment group. Mice were intraperitoneal (ip) injected by CCl4 three times a week for 4 weeks with dose of 0.5 ml / kg body weight to induce liver fibrosis injury. While, mice were orally administrated nano curcumin – chitosan mixture (100 mg : 100 mg) / 1 kg body weight 5 times a week for 4 weeks as a technique of prevention and treatment. Results: The results showed that nano curcumin – chitosan mixture exerted a great potential as antifibrotic agent and it was showed clearly through regulation of different parameters measured in this study such liver enzymes (ALT, AST & ALP), AFP, Caspase-3, oxidative stress biomarker (MDA), antioxidant activities (GSH & CAT) and histopathological study. | ||||
| Keywords | ||||
| Curcumin; Chitosan; Nanoparticles; Mice; Liver fibrosis. | ||||
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