THE USE OF BINARY ETHYLENIMINE AND FORMALIN AS INACTIVANTS FOR PRODUCTION OF INACTIVATED NEWCASTLE DISEASE VACCINE | ||||
| Assiut Veterinary Medical Journal | ||||
| Article 13, Volume 35.1, Issue 69, April 1996, Page 157-168 PDF (2.86 MB) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/avmj.1996.183939 | ||||
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| Authors | ||||
| SOAD, M. SOLIMAN; AFAF HAMDY; WAFAA, A. ZAGHLOUL; F. EL-BORDINY | ||||
| Abstract | ||||
| The use of Binary Ethylenimine as inactivant for Newcastle virus give a promising result as it has no effect on the antiginecity of the virus when used or 0,03 M at the same time it had completely in a concentration of 0.01M reduced the virulence of the virus within 6 to 8 hours according to the concentation. This results were superior than the results obtained when using INACTIVATION OF NEWCASTLE VACCINE formaldehyde solution as inactivant in concentration of 0.1% or 0.2% which significantly reduced antigencity from 1024 to 32 HA titer. The experimental prepared batches of Binary in- activated vaccine as compared with formalin inactivated prepared vaccine by different adjuvents (oil-gel) proved that the BEI 0.01M with oil as adjuvent was the best as it gives the highest 10g2 HI titer (5.3) as well as the highest protection percentage 94%. | ||||
| Keywords | ||||
| Key words: Newcastl disease; vaccine; Inactivation | ||||
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