SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NEW ARYLSULPHONYLUREA AND THIOUREA DERIVATIVES | ||||
Zagazig Journal of Pharmaceutical Sciences | ||||
Article 6, Volume 8, Issue 2, December 1999, Page 40-45 PDF (2.59 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjps.1999.184156 | ||||
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Authors | ||||
Mansour Abou-Kull 1; Magdy Amer2 | ||||
1Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt | ||||
2Department of Pharmacology, Faculty of Veterinary Medicine, University of Mansoura, Egypt. | ||||
Abstract | ||||
Certain arylsulphonylureas and thioureas derivatives were synthesized to be tested as hypoglycemic and antimicrobial agents in comparison with glibinclamide and sulphanilamide, respectively. The interaction of 3-chloro-2-p-substitutedphenylamino-N-(4-sulphamoylphenyl) maleimide (2) or its carbamate derivatives (3) with phenylisocyanate, phenylisothiocyanate or with appropriate amine afforded the target products. Some of the new compounds showed considerable hypoglycemic and antimicrobial activities. | ||||
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