NUCLEOPHILIC CLEAVAGE OF N-SUBSTITUTED -3- OXO- 2,3- DIHYDRO BENZO (d) - 1,2 -THIAZOLE-1,1-DIOXIDE WITH HYDRAZINE HYDRATE
Al-Ashmawi, M., Abdel-Aziz, L., Mustafa, S. (1999). NUCLEOPHILIC CLEAVAGE OF N-SUBSTITUTED -3- OXO- 2,3- DIHYDRO BENZO (d) - 1,2 -THIAZOLE-1,1-DIOXIDE WITH HYDRAZINE HYDRATE. EKB Journal Management System, 8(1), 47-52. doi: 10.21608/zjps.1999.184165
Mohamed Al-Ashmawi; Lobna Abdel-Aziz; Samia Mustafa. "NUCLEOPHILIC CLEAVAGE OF N-SUBSTITUTED -3- OXO- 2,3- DIHYDRO BENZO (d) - 1,2 -THIAZOLE-1,1-DIOXIDE WITH HYDRAZINE HYDRATE". EKB Journal Management System, 8, 1, 1999, 47-52. doi: 10.21608/zjps.1999.184165
Al-Ashmawi, M., Abdel-Aziz, L., Mustafa, S. (1999). 'NUCLEOPHILIC CLEAVAGE OF N-SUBSTITUTED -3- OXO- 2,3- DIHYDRO BENZO (d) - 1,2 -THIAZOLE-1,1-DIOXIDE WITH HYDRAZINE HYDRATE', EKB Journal Management System, 8(1), pp. 47-52. doi: 10.21608/zjps.1999.184165
Al-Ashmawi, M., Abdel-Aziz, L., Mustafa, S. NUCLEOPHILIC CLEAVAGE OF N-SUBSTITUTED -3- OXO- 2,3- DIHYDRO BENZO (d) - 1,2 -THIAZOLE-1,1-DIOXIDE WITH HYDRAZINE HYDRATE. EKB Journal Management System, 1999; 8(1): 47-52. doi: 10.21608/zjps.1999.184165

NUCLEOPHILIC CLEAVAGE OF N-SUBSTITUTED -3- OXO- 2,3- DIHYDRO BENZO (d) - 1,2 -THIAZOLE-1,1-DIOXIDE WITH HYDRAZINE HYDRATE

Zagazig Journal of Pharmaceutical Sciences
Article 6, Volume 8, Issue 1, June 1999, Page 47-52  XML PDF (2.51 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1999.184165
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Authors
Mohamed Al-Ashmawi email 1; Lobna Abdel-Aziz2; Samia Mustafa2
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
2Department of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Zagazig -Egypt.
Abstract
The reaction profile of certain 2-substituted-3-oxo-2,3- dihydrobenzo (d)-1,2- thiazole-1,1-dioxide (N-substitued saccharines) with hydrazine hydrate is described. It was found that the steric hindrance displayed by the substituents at position-2 has a profound effect on reaction rate. Some of the synthesized compounds were subjected to preliminary antimicrobial activity.
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