Assessment of SerumYkl-40 and High Sensitivity C-Reactive Protein as Biomarkers of Renal Affection of Children with Type 1 Diabetes
Tolba, S., Abd-Elrahman, H., Mohamed, R., Hendi, K. (2021). Assessment of SerumYkl-40 and High Sensitivity C-Reactive Protein as Biomarkers of Renal Affection of Children with Type 1 Diabetes. EKB Journal Management System, 84(1), 2337-2343. doi: 10.21608/ejhm.2021.184221
Sabry Abdel Rahman Tolba; Hadeel Mohammad Abd-Elrahman; Randa Hussiny Mohamed; Khaled Abdulhafid Moftah Hendi. "Assessment of SerumYkl-40 and High Sensitivity C-Reactive Protein as Biomarkers of Renal Affection of Children with Type 1 Diabetes". EKB Journal Management System, 84, 1, 2021, 2337-2343. doi: 10.21608/ejhm.2021.184221
Tolba, S., Abd-Elrahman, H., Mohamed, R., Hendi, K. (2021). 'Assessment of SerumYkl-40 and High Sensitivity C-Reactive Protein as Biomarkers of Renal Affection of Children with Type 1 Diabetes', EKB Journal Management System, 84(1), pp. 2337-2343. doi: 10.21608/ejhm.2021.184221
Tolba, S., Abd-Elrahman, H., Mohamed, R., Hendi, K. Assessment of SerumYkl-40 and High Sensitivity C-Reactive Protein as Biomarkers of Renal Affection of Children with Type 1 Diabetes. EKB Journal Management System, 2021; 84(1): 2337-2343. doi: 10.21608/ejhm.2021.184221

Assessment of SerumYkl-40 and High Sensitivity C-Reactive Protein as Biomarkers of Renal Affection of Children with Type 1 Diabetes

The Egyptian Journal of Hospital Medicine
Article 112, Volume 84, Issue 1, July 2021, Page 2337-2343  XML
Document Type: Original Article
DOI: 10.21608/ejhm.2021.184221
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Authors
Sabry Abdel Rahman Tolba; Hadeel Mohammad Abd-Elrahman; Randa Hussiny Mohamed; Khaled Abdulhafid Moftah Hendi
Abstract
Background: Diabetes describes a group of metabolic disorders characterized and identified by the presence of hyperglycemia in the absence of treatment.
Objective: The aim of this study was early detection of renal affection in children with type 1 diabetes (T1DM) by using serumYkl-40 and high sensitivity C-reactive protein (Hs-CRP) as biomarker.
Patients and methods: This study was a case control study carried out at Pediatric Department, in pediatric endocrine inpatient and outpatient clinic, Zagazig University Hospitals from October 2019 to October 2020. It included 57 participants collected from Pediatric Department in Zagazig University Hospital who were divided into 3 groups; each group included (19) patients.1st group was diabetic group with normoalbuminuria (<30 mg/g creatinine), 2nd group was diabetic group with microalbuminuria (30-299 mg/g creatinine), and the 3rd group was healthy children.
Results : The serumYkl-40 and Hs-CRP were good predictor markers for prediction of renal affection among children with T1DM with (86.8% and 94.7%) ability truly diagnose renal affection, (72.0% and 84.2%) ability to exclude truly negative ones and total (80.7% and 91.2%) accuracy for serumYkl-40 and Hs-CRP respectively.
 Conclusion: YKL-40 and Hs-CRP levels could be used as tools to assess the risk of diabetic microangiopathy in the very early stage in T1DM patients.
 
Keywords
Diabetes mellitus; Diabetic nephropathy (DN); High sensitivity C-reactive protein; SerumYkl-40
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