HPLC DETERMINATION OF AMOXICILLIN, AMPICILLIN, PHENOXYMETHYLPENIČILLIN, FLUCLOXACILLIN, CLOXACILLIN AND DICLOXACILLIN IN PHARMACEUTICAL PREPARATIONS
El Sayed, K., Younis, M., El-Shanawany, A. (1998). HPLC DETERMINATION OF AMOXICILLIN, AMPICILLIN, PHENOXYMETHYLPENIČILLIN, FLUCLOXACILLIN, CLOXACILLIN AND DICLOXACILLIN IN PHARMACEUTICAL PREPARATIONS. EKB Journal Management System, 7(1), 38-47. doi: 10.21608/zjps.1998.184809
Khaled El Sayed; Mohamed Younis; Abdallah El-Shanawany. "HPLC DETERMINATION OF AMOXICILLIN, AMPICILLIN, PHENOXYMETHYLPENIČILLIN, FLUCLOXACILLIN, CLOXACILLIN AND DICLOXACILLIN IN PHARMACEUTICAL PREPARATIONS". EKB Journal Management System, 7, 1, 1998, 38-47. doi: 10.21608/zjps.1998.184809
El Sayed, K., Younis, M., El-Shanawany, A. (1998). 'HPLC DETERMINATION OF AMOXICILLIN, AMPICILLIN, PHENOXYMETHYLPENIČILLIN, FLUCLOXACILLIN, CLOXACILLIN AND DICLOXACILLIN IN PHARMACEUTICAL PREPARATIONS', EKB Journal Management System, 7(1), pp. 38-47. doi: 10.21608/zjps.1998.184809
El Sayed, K., Younis, M., El-Shanawany, A. HPLC DETERMINATION OF AMOXICILLIN, AMPICILLIN, PHENOXYMETHYLPENIČILLIN, FLUCLOXACILLIN, CLOXACILLIN AND DICLOXACILLIN IN PHARMACEUTICAL PREPARATIONS. EKB Journal Management System, 1998; 7(1): 38-47. doi: 10.21608/zjps.1998.184809

HPLC DETERMINATION OF AMOXICILLIN, AMPICILLIN, PHENOXYMETHYLPENIČILLIN, FLUCLOXACILLIN, CLOXACILLIN AND DICLOXACILLIN IN PHARMACEUTICAL PREPARATIONS

Zagazig Journal of Pharmaceutical Sciences
Article 4, Volume 7, Issue 1, June 1998, Page 38-47  XML PDF (4.27 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1998.184809
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Authors
Khaled El Sayed email 1; Mohamed Younis2; Abdallah El-Shanawany3
1Quality Control Department, Egyptian International Pharmaceutical Industries Co.( EIPICO ),10 th of Ramadan city, Egypt.
2Department of Chemistry, Faculty of Science , Zagazig University , Egypt.
3Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt
Abstract
A simple high performance liquid chromatographic procedure was described for the determination of amoxicillin, ampicillin, cloxacillin, dicloxacillin, flucloxacillin and phenoxymethylpenicillin (penicillin V) in single or combined pharmaceutical formulations. The drugs were chromatographed on an Ultrasphere ODS column and (40% methanol containing 9 mM-sodium heptane sulphonate, 30 mM-potassium dihydrogen phosphate and 0.04% triethylamine) adjusted to pH 5 with 1 M-phosphoric acid as mobile phase using penicillin G as internal standard. The flow rate was 1 ml.min.-1 at 230 nm detection. The results show good accuracy as shown by the % recovery of 99.61, 99.53, 99.9, 100,08, 100.18 and 99.908 and high precision as shown by the relative standard deviation, RSD 0.744, 0.613, 0.557, 0.731, 0.46 and 0.308
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