QUANTITATIVE DETERMINATION OF OFLOXACIN AND CIPROFLOXACIN HYDROCHLORIDE IN THE PRESENCE OF SOME RELATED SUBSTANCES IN PHARMACEUTICAL PREPARATIONS USING HPLC | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 6, Volume 7, Issue 1, June 1998, Page 54-58 PDF (2.73 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.1998.184811 | ||||
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| Authors | ||||
Abdalla El-Shanawani  1; Sobhy El-Adl2; Abd El-Aziz El- Bayoumi3
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| 1Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. | ||||
| 2Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt | ||||
| 3Analytical Chem. Department, Faculty of Pharmacy, Cairo University, Egypt | ||||
| Abstract | ||||
| An analytical method for the determination of ofloxacin or ciprofloxacin hydrochloride in pharmaceutical preparations by high performance liquid chromatography was developed. Piperazine, triethylformate, 3-chloro-4-fluoroaniline and 1,3-dichloro-4-fluorobenzene do not interfere with the analysis of ofloxacin. Also, cyclopropylamine, piperazine hexahydrate, ethylene diamine ciprofloxacin analog, 3- chloro-4- fluoroaniline, 1,3-dichloro-4-fluorobenzene and fluoroquinolonic acid do not Haterfere with the analysis of ciprofloxacin Salicylic acid was used as internal standard and the mobile phase consisted of a mixture of 35% methanol in 0.05 M sodium dihydrogen phosphate and the pH adjusted to 2.8 at flow rate 1 ml min-1. The chromatographic separation was achieved on Lichrospher 60-RP column with ultraviolet detection at 274 nm. The BOcratic system was operated at ambient temperature and required 8 min of chromatographic time. The method was applied to Tanvid® tablets and Ciprinol ® ampoules with relative standard deviation 0.75 and 1.62, respectively. | ||||
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