COMPARATIVE STUDY ON INCLUSION COMPLEXATION OF HEPTAKIS (2,6-di-O-METHYL)-β- CYCLODEXTRIN, β-CYCLODEXTRIN AND ɣ-CYCLODEXTRIN WITH KETOCONAZOLE IN AQUEOUS SOLUTION AND SOLID STATE.
EL-Sayed, M., Bosela, A. (1998). COMPARATIVE STUDY ON INCLUSION COMPLEXATION OF HEPTAKIS (2,6-di-O-METHYL)-β- CYCLODEXTRIN, β-CYCLODEXTRIN AND ɣ-CYCLODEXTRIN WITH KETOCONAZOLE IN AQUEOUS SOLUTION AND SOLID STATE.. EKB Journal Management System, 7(1), 87-93. doi: 10.21608/zjps.1998.184817
Mohamed M EL-Sayed; Ahmed Bosela. "COMPARATIVE STUDY ON INCLUSION COMPLEXATION OF HEPTAKIS (2,6-di-O-METHYL)-β- CYCLODEXTRIN, β-CYCLODEXTRIN AND ɣ-CYCLODEXTRIN WITH KETOCONAZOLE IN AQUEOUS SOLUTION AND SOLID STATE.". EKB Journal Management System, 7, 1, 1998, 87-93. doi: 10.21608/zjps.1998.184817
EL-Sayed, M., Bosela, A. (1998). 'COMPARATIVE STUDY ON INCLUSION COMPLEXATION OF HEPTAKIS (2,6-di-O-METHYL)-β- CYCLODEXTRIN, β-CYCLODEXTRIN AND ɣ-CYCLODEXTRIN WITH KETOCONAZOLE IN AQUEOUS SOLUTION AND SOLID STATE.', EKB Journal Management System, 7(1), pp. 87-93. doi: 10.21608/zjps.1998.184817
EL-Sayed, M., Bosela, A. COMPARATIVE STUDY ON INCLUSION COMPLEXATION OF HEPTAKIS (2,6-di-O-METHYL)-β- CYCLODEXTRIN, β-CYCLODEXTRIN AND ɣ-CYCLODEXTRIN WITH KETOCONAZOLE IN AQUEOUS SOLUTION AND SOLID STATE.. EKB Journal Management System, 1998; 7(1): 87-93. doi: 10.21608/zjps.1998.184817

COMPARATIVE STUDY ON INCLUSION COMPLEXATION OF HEPTAKIS (2,6-di-O-METHYL)-β- CYCLODEXTRIN, β-CYCLODEXTRIN AND ɣ-CYCLODEXTRIN WITH KETOCONAZOLE IN AQUEOUS SOLUTION AND SOLID STATE.

Zagazig Journal of Pharmaceutical Sciences
Article 11, Volume 7, Issue 1, June 1998, Page 87-93  XML PDF (4.37 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1998.184817
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Authors
Mohamed M EL-Sayed email 1; Ahmed Bosela2
1Dept. of Pharmaceutics, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
2Dept. of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Egypt.
Abstract
The interaction of Ketoconazole with three kinds of cyclodextrins, β-, ɣ- and dimethyl β-cyclodextrin in aqueous solution and solid state was investigated to improve solubility and dissolution rate of the drug. For β- and dimethyl-ß-cyclodextrin, drug solubility increased linearly as a function of cyclodextrin concentration and the solubility curve could be classified as Higuchi AL type which indicated the formation of soluble complexes. Complexation with y-cyclodextrin, however, yielded a Bs type solubility curve. The solid cormplexes in all cases were obtained in a molar ratio of 1:1. The inclusion complexes of the drug with the three Cyclodextrins were investigated using DSC and powder X-ray diffractometry and their dissolution behaviour were examined The dissolution rate of Ketoconazole-dimethyl-β-cyclodextrin complex was significantly faster than other complexes due to its high aqueous solubility and amorphous structure. It was concluded that cyclodextrins may be used to enhance the solubility and dissolution rate of Ketoconazole in water.
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