SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL HETEROCYCLIC DERIVATIVES OF FLURBIPROFEN | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 12, Volume 7, Issue 1, June 1998, Page 94-100 PDF (4.12 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.1998.184818 | ||||
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| Authors | ||||
Mohamed El-Sadek  1; Lobna Abdel-Aziz2; Mansour Abou-Kull3; Kamel Metwally4
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| 1Dept. of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Zagazig , Egypt | ||||
| 2Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt | ||||
| 3Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt | ||||
| 4Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig. Egypt | ||||
| Abstract | ||||
| The synthesis of some novel non- carboxylic heterocyclic derivatives of flurbiprofen such as pyrazole , pyrrole , oxadiazole, oxadiazines, and triazoles, is described. Structure of the new compounds was elucidated by spectroscopic data and microanalysis. Three representative compounds were tested for analgesic, antipyretic, and anti-inflammatory activities. The pyrazole derivative VIII displayed greater antipyretic activity but lower analgesic and anti-inflammatory activities compared to flurbiprofen. However, the other two compounds were , in general, less potent than flurbiprofen. | ||||
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