APROTININ INHIBITED ACUTE PANCREATITIS INDUCED BY HYDROCHLOROTHIAZIDE AND FUROSEMIDE IN EXPERIMENTIAL ANIMALS
Mohamed, H., Yacoub, H., El-Melegy, S., Gouda, N. (1997). APROTININ INHIBITED ACUTE PANCREATITIS INDUCED BY HYDROCHLOROTHIAZIDE AND FUROSEMIDE IN EXPERIMENTIAL ANIMALS. EKB Journal Management System, 6(2), 38-43. doi: 10.21608/zjps.1997.184942
Hoda Mohamed; Hazar Yacoub; Salwa El-Melegy; Nadia Gouda. "APROTININ INHIBITED ACUTE PANCREATITIS INDUCED BY HYDROCHLOROTHIAZIDE AND FUROSEMIDE IN EXPERIMENTIAL ANIMALS". EKB Journal Management System, 6, 2, 1997, 38-43. doi: 10.21608/zjps.1997.184942
Mohamed, H., Yacoub, H., El-Melegy, S., Gouda, N. (1997). 'APROTININ INHIBITED ACUTE PANCREATITIS INDUCED BY HYDROCHLOROTHIAZIDE AND FUROSEMIDE IN EXPERIMENTIAL ANIMALS', EKB Journal Management System, 6(2), pp. 38-43. doi: 10.21608/zjps.1997.184942
Mohamed, H., Yacoub, H., El-Melegy, S., Gouda, N. APROTININ INHIBITED ACUTE PANCREATITIS INDUCED BY HYDROCHLOROTHIAZIDE AND FUROSEMIDE IN EXPERIMENTIAL ANIMALS. EKB Journal Management System, 1997; 6(2): 38-43. doi: 10.21608/zjps.1997.184942

APROTININ INHIBITED ACUTE PANCREATITIS INDUCED BY HYDROCHLOROTHIAZIDE AND FUROSEMIDE IN EXPERIMENTIAL ANIMALS

Zagazig Journal of Pharmaceutical Sciences
Article 8, Volume 6, Issue 2, December 1997, Page 38-43  XML PDF (4.47 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1997.184942
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Authors
Hoda Mohamed email ; Hazar Yacoub; Salwa El-Melegy; Nadia Gouda
Department of Pharmacology, Faculty of Pharmacy King Saud University, Riyadh, Saudi Arabia
Abstract
The effect of the Kallikrein inhibitor, aprotinin, on hydrochlorothiazide and furosemide inducing pancreatitis has been studied in male rats. Treatment of animals with hydrochlorothiazide and furosemide for two weeks significantly increased serum lipase, amylase and glucose levels. The drugs therapy markedly reduced serum potassium level. Concurrent administration of aprotinin with hydrochlorothiazide and furosemide succeeded to ameliorate the elevated levels of serum lipase, amylase and glucose. Aprotinin failed to correct the hypokalemic effect of diuretics therapy. Histopathological studies revealed that aprotinin improved the picture of the pancreas and beta-cells which were partialy destroyed by hydrochlorothiazide and furosemide.
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