CRECTROPHOTOMETRIC DETERMINATION OF PHENYLBUTAZONE AND OXYPHENBUTAZONE THROUGH CONDENSATION WITH P-DIMETHYLAMINOBENZALDEHYDE
Rücker, G., Ayad, M., El-Sadek, M., Moustafa, S. (1997). CRECTROPHOTOMETRIC DETERMINATION OF PHENYLBUTAZONE AND OXYPHENBUTAZONE THROUGH CONDENSATION WITH P-DIMETHYLAMINOBENZALDEHYDE. EKB Journal Management System, 6(2), 81-85. doi: 10.21608/zjps.1997.184947
Gehard Rücker; Magda Ayad; Mohamed El-Sadek; Samia Moustafa. "CRECTROPHOTOMETRIC DETERMINATION OF PHENYLBUTAZONE AND OXYPHENBUTAZONE THROUGH CONDENSATION WITH P-DIMETHYLAMINOBENZALDEHYDE". EKB Journal Management System, 6, 2, 1997, 81-85. doi: 10.21608/zjps.1997.184947
Rücker, G., Ayad, M., El-Sadek, M., Moustafa, S. (1997). 'CRECTROPHOTOMETRIC DETERMINATION OF PHENYLBUTAZONE AND OXYPHENBUTAZONE THROUGH CONDENSATION WITH P-DIMETHYLAMINOBENZALDEHYDE', EKB Journal Management System, 6(2), pp. 81-85. doi: 10.21608/zjps.1997.184947
Rücker, G., Ayad, M., El-Sadek, M., Moustafa, S. CRECTROPHOTOMETRIC DETERMINATION OF PHENYLBUTAZONE AND OXYPHENBUTAZONE THROUGH CONDENSATION WITH P-DIMETHYLAMINOBENZALDEHYDE. EKB Journal Management System, 1997; 6(2): 81-85. doi: 10.21608/zjps.1997.184947

CRECTROPHOTOMETRIC DETERMINATION OF PHENYLBUTAZONE AND OXYPHENBUTAZONE THROUGH CONDENSATION WITH P-DIMETHYLAMINOBENZALDEHYDE

Zagazig Journal of Pharmaceutical Sciences
Article 13, Volume 6, Issue 2, December 1997, Page 81-85  XML PDF (2.23 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1997.184947
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Authors
Gehard Rücker* 1; Magda Ayad2; Mohamed El-Sadek3; Samia Moustafa3
1Pharmacy Institute, Bonn University, Germany
2Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University. Zagazig. Egypt.
3Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt
Abstract
P-Dimethylaminobenzaldehyde is used for colorimetric determination of phenylbutazone and oxyphenbutazone both in pure form and in their tablets. The reaction proceeds via first formation of aldol intermediate which suffers aminolysis by piperidine with subsequent elimination to afford intensive and stable colored disubstituted styrene. Beer's law is obeyed in the range of 0.08-0.4 mg mg-1 for phenylbutazone and 0.08-0.24 mg ml for oxyphenbutazone.
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