UIITY OF 2- HYDRAZIN04,6 DIMETHYLPYRIMIDINE IN HETEROCY CLIC SYNTHESIS
AL Ashmawy, M., Abd El-Samii, Z., El-Feky, S., Osman, N. (1997). UIITY OF 2- HYDRAZIN04,6 DIMETHYLPYRIMIDINE IN HETEROCY CLIC SYNTHESIS. EKB Journal Management System, 6(1), 7-11. doi: 10.21608/zjps.1997.184948
Mohamed AL Ashmawy; Zakaria Abd El-Samii; Said El-Feky; Nermin Osman. "UIITY OF 2- HYDRAZIN04,6 DIMETHYLPYRIMIDINE IN HETEROCY CLIC SYNTHESIS". EKB Journal Management System, 6, 1, 1997, 7-11. doi: 10.21608/zjps.1997.184948
AL Ashmawy, M., Abd El-Samii, Z., El-Feky, S., Osman, N. (1997). 'UIITY OF 2- HYDRAZIN04,6 DIMETHYLPYRIMIDINE IN HETEROCY CLIC SYNTHESIS', EKB Journal Management System, 6(1), pp. 7-11. doi: 10.21608/zjps.1997.184948
AL Ashmawy, M., Abd El-Samii, Z., El-Feky, S., Osman, N. UIITY OF 2- HYDRAZIN04,6 DIMETHYLPYRIMIDINE IN HETEROCY CLIC SYNTHESIS. EKB Journal Management System, 1997; 6(1): 7-11. doi: 10.21608/zjps.1997.184948

UIITY OF 2- HYDRAZIN04,6 DIMETHYLPYRIMIDINE IN HETEROCY CLIC SYNTHESIS

Zagazig Journal of Pharmaceutical Sciences
Article 2, Volume 6, Issue 1, June 1997, Page 7-11  XML PDF (3.17 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1997.184948
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Authors
Mohamed AL Ashmawy email 1; Zakaria Abd El-Samii2; Said El-Feky2; Nermin Osman2
1Department of Organic Pharmaceutical Chemistry, Facutly of Pharmacy Zagazig University. Zagazig Egypt
2Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
Abstract
2-Hydrazino-4,6-dimethy1pyridine (1) readily underwent ring closure with benzoy1 chloride to give 5,7 dimethy1-3-pheny1-1,2,4-triazolo[4,3,-a]pyrimidine (4a). Either N-benzoyl derivative (2) or the hydrazone (3a) can be used for the formation of compound 4a. Reaction of compound 1 with acetylacetone gave the pyrazole derivative (6) rather than 1.2.4 triazepine derivative (5).The pyrrole (8) was the sole product from cyclization of 1 with 2.5- hexanedione. Reaction of compound 1 with carbon disulphide or ethy1 chloroformate gave 1,2,4-triazolo[4,3-a]pyrimidines (9 and 11) respectively . The reaction of thiosemicarbazides (12 a-c) with ethy1 bromoacetate and DCCD was investigated.
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