SOME ADVERSE EFFECTS OF LAMBDA- CYHALOTHRIN (ICON 1 E)® THE MOST RECENT SYNTHETIC PYRETHROIDAL INSECTICIDE | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 3, Volume 6, Issue 1, June 1997, Page 12-20 PDF (5.76 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.1997.184949 | ||||
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| Authors | ||||
Gamal Shams  1; Abd El- Alim Abdel El-Alim1; Mohamed El Sayed2; Taha Mohamed1
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| 1Pharmacology Department, Faculty of Vet. Med., Zagazig University, Egypt | ||||
| 2Department of Pharmacology, Faculty of Vet: Med., Mansoura University. | ||||
| Abstract | ||||
| Lambda-cyhalothrin which is a recent pyrethroid insecticidal agent, elicited a concentration dependent negative inotropic and choronotropic effects on isolated perfused rabbit heart with an increase in coronary outflow which might be of cholinergic nature. A relaxant effect was achieved on the rat thoracic aortic strip preparations which was abolished in presence of atropine indicating the acetyl choline like effect of the compound. Lambda- cyhalothrin produced stimulatory effect followed by relaxation on rat phrenic nerve diaphragm preparation indicating the depolarizing neuromuscular blocking activity of the drug. A transient hypotensive effect was traced, the effect revealed the peripheral cholinergic effects of the compound. Moreover, spraying healthy rabbits with lambda- cyhalothrin for 5 successive days in an effective concentration (1mg/40 ml) did not produce any changes on the blood picture, liver and kidney functions. Meanwhile the compound sprayed in double effective concentration (2mg/40ml) induced a significant decrease in erythrocytes , leucocyte counts, Hb% and P. C. V. % with a significant prolonged prothrombin time after 14,21 and 28 days of last spray. It also elicited a significant elevation of SAST, SALT, alkaline phosphatase, serum bilirubin, blood urea nitrogen, creatinine and uric acid. | ||||
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