A NEW APPLICATION OF MEBEVERINE-HYDROCHLORIDE AS A LOCAL ANAESTHETIC DRUG | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 5, Volume 5, Issue 2, December 1996, Page 26-31 PDF (2.84 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.1996.185012 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Seham Abdel-Hady 
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| Department of Pharmaceutics, Faculty of Pharmacy, Helwan University, Cairo, Egypt. | ||||
| Abstract | ||||
| The efficiency of the well known antispasmodic drug mebeverine-hydrochloride, as a local anaesthetic was evaluated. The drug was formulated into different ointment and gel bases. The prepared topical applications were evaluated for the in vitro release of the drug and for the local anaesthetic effect on the rabbit's eye. The release profile agreed with the first order kinetics, the release rate and the duration of action of the drug was found to be a function of type of base. Carbopol 934 gel gave the longest duration of action (113 minutes), the polyethylen glycol base gave a moderate duration (50 minutes), while the shortest duration of action (15 minutes) was achieved in case of hydrophilic petrolatum. | ||||
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