IN-VITRO ANTIMICROBIAL ACTIVITY OF CHLORHEXIDINE POLYMERIC FILMS
Salama, M., Ghazy, F., Abu-Zaid, S., Abdelrahman, A., Al-Areeky, A. (1996). IN-VITRO ANTIMICROBIAL ACTIVITY OF CHLORHEXIDINE POLYMERIC FILMS. EKB Journal Management System, 5(2), 71-76. doi: 10.21608/zjps.1996.185018
Mohamed Salama; Fakher Ghazy; Samir Abu-Zaid; Ali Abdelrahman; Ahmed Al-Areeky. "IN-VITRO ANTIMICROBIAL ACTIVITY OF CHLORHEXIDINE POLYMERIC FILMS". EKB Journal Management System, 5, 2, 1996, 71-76. doi: 10.21608/zjps.1996.185018
Salama, M., Ghazy, F., Abu-Zaid, S., Abdelrahman, A., Al-Areeky, A. (1996). 'IN-VITRO ANTIMICROBIAL ACTIVITY OF CHLORHEXIDINE POLYMERIC FILMS', EKB Journal Management System, 5(2), pp. 71-76. doi: 10.21608/zjps.1996.185018
Salama, M., Ghazy, F., Abu-Zaid, S., Abdelrahman, A., Al-Areeky, A. IN-VITRO ANTIMICROBIAL ACTIVITY OF CHLORHEXIDINE POLYMERIC FILMS. EKB Journal Management System, 1996; 5(2): 71-76. doi: 10.21608/zjps.1996.185018

IN-VITRO ANTIMICROBIAL ACTIVITY OF CHLORHEXIDINE POLYMERIC FILMS

Zagazig Journal of Pharmaceutical Sciences
Article 11, Volume 5, Issue 2, December 1996, Page 71-76  XML PDF (1.8 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1996.185018
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Authors
Mohamed Salama email 1; Fakher Ghazy2; Samir Abu-Zaid3; Ali Abdelrahman4; Ahmed Al-Areeky5
1Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University Zagazig - Egypt.
2Department of Pharmaceutics and Industrial Pharmacy. Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University Egypt.
4Department of Microbiology, Faculty of Pharmacy, Zagazig University, Egypt.
5Department of Pharmaceutics, Faculty of Medicine and Health Science Sana'a University.
Abstract
The minimum inhibitory concentration (MIC) of chlorhexidine for Staphylococcus aureus, Bacillus subtilus, Escherichia Coli and Candida albicans was studied. Chlorhexidine polymeric films composed of ethylcellulose (EC) and hydroxypropyl methyl- cellulose (HPMC) in a ratio of 8:2 were prepared. The inhibition zone diameters of chlorhexidine polymeric film were compared with that of chlorhexidine gauze dressing. Also, the inhibition zone sizes of different concentrations of chlorhexidine (0.5, 1 and 5%) in films plasticized with 20% propylene glycol, in presence of 10% Tween 80 as enhancer, or plasticized with 20% polyethylene glycol 400 were evaluated. Results indicated that the MIC of chlorhexidine was ranged from 1 to 1.8 ug/ml. Also the inhibition zone diameters of the selected polymeric film was higher than that of gauze dressing. There were correlation between drug concentrations and inhibition zone sizes. Also polymeric film containing 20% propylene glycol and 10% Tween 80 showed relatively higher response than polymeric film containing 20% ployethylene glycol 400. It can be concluded that the tested microorganisms were susceptible to chlorhexidine and the use of polymeric films as drug delivery system enhanced chlorhexidine in-vitro antimicrobial activity. Accordingly, it was recommended to use chlorhexidine polymeric films for topical antisepsis.
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