EFFECT OF IVERMECTIN ON FEMALE FERTILITY AND TERATOGENICITY IN RATS | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 17, Volume 5, Issue 2, December 1996, Page 113-124 PDF (5.77 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.1996.185031 | ||||
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| Authors | ||||
Sawsan EI Sheikh  1; Sabry Abd El-Motal1; Abd-El Alim Abd-El Alim2; Naeema Afifi3; Gehan Ahmed4
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| 1Dept. of Pharmacology, Faculty of Vet. Medicine, Zagazig University | ||||
| 2Depart. of Pharmacology, Faculty of Vet. Medicine , Zagazig University, Zagazig, Egypt. | ||||
| 3Animal Health Research Institute, Dokki, Giza, Egypt | ||||
| 4Animal Health Research Institute ,Zagazig Branch, Egypt. | ||||
| Abstract | ||||
| Ivermectin has gained a good reputation as the drug of choice having a broad spectrum nematocidal, insecticidal and acaricidal activities. Nevertheless, the seemingly promising future use of Ivermectin, could be highly precluded by its side effects. The study pointed out that, ivermectin prolonged the oestrus phase in 40% of the examined females in the first group and 60% in the second group the observed morphological deformities in response to ivermectin injection were mostly the presence of red patches in different parts of the body, swelling above the eyes and protrusion of the intestine from the abdomen. The most frequently encountered desirable internal malformations in response to ivermectin injection at a dose of 0.2 and 0.4 mg/kg b.wt. were; cleft palate, thickening of the ventricular wall of the heart, haemorrhage around brain and dilatation of renal pelvis. Skeletal malformations in response to both doses of ivermectin were; incomplete ossification of the cranium, absence of the last coccygeal vertebrae, rudimentary or missing sternebrae and tiphisternums and absence of phalanges of both the fore and hind limbs. | ||||
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