CD96 as a Leukemic Stem Cell Marker in Acute Myeloid Leukemia Patients: Relation to Remission Induction Chemotherapy | ||||
| The Medical Journal of Cairo University | ||||
| Article 109, Volume 89, June, June 2021, Page 1325-1331 PDF (395.32 K) | ||||
| DOI: 10.21608/mjcu.2021.185043 | ||||
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| Authors | ||||
| MOHAMED A. FATEEN, M.D.; RASHA RAWI, M.D.; HEBA E. ABD EL-RAHMAN, M.Sc.; SAHAR K. HUSSEIN, M.D. | ||||
| The Department of Clinical & Chemical Pathology*, Clinical Hematology Unit, Internal Medicine Department**, Faculty of Medicine, Cairo University and Clinical & Chemical Pathology, Armed Forces Central Laboratory*** | ||||
| Abstract | ||||
| Abstract Background: Leukemic stem cells (LSCs) play a crucial role in chemotherapy resistance in acute myeloid leukemia (AML), the classical LSCs phenotype is CD34+/CD38-. Successful eradication of LSCs requires combination of different strategies including targeting LSC specific surface molecules. Aim of Study: To investigate the role of CD96, as a stem cell marker, in AML and its relation to induction therapy outcome. Material and Methods: The current study was conducted on 50 patients with de-novo AML, in addition to 20 controls. Using multicolor flow cytometry, we analyzed the expression of CD96, a potential marker for LSCs among CD34+/CD38- cell population in AML patients at initial diagnosis and correlate it to the response of induction therapy. Results: Percentage of CD96 among CD34+/CD38- was significantly higher in AML patients compared to control group (p < 0.001). However, no statistical significant difference was observed between complete remission (CR) and non-remission (NCR) groups. Also the correlation studies of LSC markers with laboratory findings revealed no significant correlation. Conclusions: CD96 expression among CD34+/CD38- cells may be used as a useful marker for detection of LSCs in AML patients. However its expression is not correlated to post induction therapy outcome. | ||||
| Keywords | ||||
| Acute myeloid leukemia (AML); Leukemic stem cell (LSC); CD96; Induction therapy | ||||
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