SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN FLURBIPROFEN DERIVATIVES
El-Sadek, M., Abdel-Aziz, L., Abdel-Rahem, K. (1996). SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN FLURBIPROFEN DERIVATIVES. EKB Journal Management System, 5(1), 29-35. doi: 10.21608/zjps.1996.185049
Mohamed El-Sadek; Lobna Abdel-Aziz; Kamel Abdel-Rahem. "SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN FLURBIPROFEN DERIVATIVES". EKB Journal Management System, 5, 1, 1996, 29-35. doi: 10.21608/zjps.1996.185049
El-Sadek, M., Abdel-Aziz, L., Abdel-Rahem, K. (1996). 'SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN FLURBIPROFEN DERIVATIVES', EKB Journal Management System, 5(1), pp. 29-35. doi: 10.21608/zjps.1996.185049
El-Sadek, M., Abdel-Aziz, L., Abdel-Rahem, K. SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN FLURBIPROFEN DERIVATIVES. EKB Journal Management System, 1996; 5(1): 29-35. doi: 10.21608/zjps.1996.185049

SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN FLURBIPROFEN DERIVATIVES

Zagazig Journal of Pharmaceutical Sciences
Article 4, Volume 5, Issue 1, June 1996, Page 29-35  XML PDF (4.57 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1996.185049
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Authors
Mohamed El-Sadek email 1; Lobna Abdel-Aziz2; Kamel Abdel-Rahem3
1Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt
2Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt
3Department of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Egypt.
Abstract
The synthesis of several flurbiprofen amides and hydrazones is described. Structures of the new compounds were substantiated by microanalytical and spectroscopic data. Five representative compounds were subjected to preliminary pharmacological screening which revealed that three of them exhibited superior analgesic, antipyretic and anti-inflammatory activities compared to flurbiprofen.
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