β-ADRENERGIC and THROMBOXANE A2 ACTIVITIES OF RECENT MODIFIED TRIMETOQUINOL ANALOGUES
Shams, G. (1996). β-ADRENERGIC and THROMBOXANE A2 ACTIVITIES OF RECENT MODIFIED TRIMETOQUINOL ANALOGUES. EKB Journal Management System, 5(1), 46-49. doi: 10.21608/zjps.1996.185052
Gamal Shams. "β-ADRENERGIC and THROMBOXANE A2 ACTIVITIES OF RECENT MODIFIED TRIMETOQUINOL ANALOGUES". EKB Journal Management System, 5, 1, 1996, 46-49. doi: 10.21608/zjps.1996.185052
Shams, G. (1996). 'β-ADRENERGIC and THROMBOXANE A2 ACTIVITIES OF RECENT MODIFIED TRIMETOQUINOL ANALOGUES', EKB Journal Management System, 5(1), pp. 46-49. doi: 10.21608/zjps.1996.185052
Shams, G. β-ADRENERGIC and THROMBOXANE A2 ACTIVITIES OF RECENT MODIFIED TRIMETOQUINOL ANALOGUES. EKB Journal Management System, 1996; 5(1): 46-49. doi: 10.21608/zjps.1996.185052

β-ADRENERGIC and THROMBOXANE A2 ACTIVITIES OF RECENT MODIFIED TRIMETOQUINOL ANALOGUES

Zagazig Journal of Pharmaceutical Sciences
Article 7, Volume 5, Issue 1, June 1996, Page 46-49  XML PDF (3.03 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1996.185052
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Author
Gamal Shams email
Pharmacology Department, Faculty of Vet. Med., Zagazig University, Egypt
Abstract
Several Trimetoqunoi (TMQ) derivatives were prepared and evaluated for their action on both B- adrenergic and thromboxane A2/prostaglandin H2 (TP) receptor systems. These particular derivatives explored the importance of TMQ's chiral center, the homologation of previously described N-benzyl derivatives, and various modifications of TMQ's trisubstituted benzyl group to probe receptor affinities. The results of this studies indicated that TMQ's chiral center is important for receptor interactions. Elongation of an N-Benzyl substituent fails to imporove potency, but modifications of the trisubstituted benzyl group has provided a new lead for modified TMQ derivatives with enhanced activity in TP receptor systems.
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