HAEMATOLOGICAL AND BIOCHEMICAL STUDIES OF CEFOPERAZONE, TYLOSIN AND THEIR COMBINATION IN RABBITS | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 17, Volume 5, Issue 1, June 1996, Page 115-119 PDF (3.32 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.1996.185076 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohamed Hassan  1; Mohamed Abdel- Haleem2
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| 1Department of Physiology and Biochemistry, Faculty of Veterinary Medicine, Zagazig University | ||||
| 2Department of Zoology, Faculty of Science, Zagazig University, (Benha branch), Egypt | ||||
| Abstract | ||||
| Intramuscular administration of cefoperazone, tylosin or their combination for 5 successive days in their subtherapeutic doses did not produce any harmful effects on blood, liver and kidney of rabbits. Therapeutic or double therapeutic doses of the drugs and their combination produced a significant decrease in erythrocytes, leucocytes counts, Hb% and P.C.V.% with a significant prolonged prothrombin time. It also elicited a significant elevation of SGOT, SGPT and total bilirubin without effect on alkaline phosphatase level. Moreover, the drugs induced a significant elevation of blood urea nitrogen and creatinine without any effect on uric acid level. | ||||
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