Recent Advances in Synergy Among SNARE Proteins and Multi-Subunit Tethering Complexes (MTCs) in Vesicle Trafficking and Plant Development | ||||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||||
| Article 1, Volume 13, Issue 2, December 2021, Page 1-25 PDF (980.26 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsc.2021.185131 | ||||
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| Authors | ||||
| Muneer Khoso1; Li Lixin2; Tamar Papiashvili3 | ||||
| 1Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Ministry of Education, Department of Life Science, Northeast Forestry University, Harbin 150040, China. | ||||
| 2Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Ministry of Education, Department of Life Science, Northeast Forestry University, Harbin 150040, China | ||||
| 3School of Economics and Management Ministry of Education, Northeast Forestry University, Harbin 150040, China | ||||
| Abstract | ||||
| Plants comprise an expanded endomembrane system, and transport within the network requires well-organized and accurate vesicle transport. Tethering complexes facilitate the early, exact contact among donor and acceptor membranes, operate to bring vesicles into a closer proximity for trans-SNARE complex assembly docking; these are classified as either long coiled-coil proteins or multi-subunit tethering complexes (MTCs). Numerous MTCs that function at different membrane trafficking steps have been recognized, where they function as significant interfaces between SNARE proteins, Rabs, and phosphoinositides. SNARE proteins assemble into complexes that catalyze the fusion between a donor and a target membrane. Studies of the diverse SNARE proteins provided further valuable information about vacuole biogenesis and vacuolar trafficking pathways related to cell-type specificity, plant development, growth, and the plant developed a specific traffic route to overcome environmental stress. In conclusion, tethers' selective recruitment during membrane fusion is controlled via diverse small GTPases, such as those in the RAB family. The MTCs promote SNARE complex assembly by direct interactions of MTC subunits with Q-SNAREs. A subset of MTC subunits exploits structurally similar CATCHR domains to mediate inter-subunit interactions as well as SNARE protein interactions. MTCs are subdivided into CATCHR (complexes associated with tethering containing helical rods: Dsl1, COG, GARP, EARP, and exocyst) and non‐CATCHR (TRAPP I, II and III, HOPS and CORVET) complexes based on the structure of their subunits. This review summarized new information about SNARE proteins and tethering complexes, highlight new insights about their function, and discuss current debates and future perspectives. | ||||
| Keywords | ||||
| Multi-subunit tethering complexes; SNAREs; Vesicle trafficking; Environmental stress; Vacuolar trafficking | ||||
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