Synthesis and Antiproliferative Ativity of 2,4-Bis(indol-3-yl)pyrrole Derivatives: Marine Nortopsentin Analogs
Rdwan, M., alrugaie, O., Al Abdulmonem, W., Alfaifi, M., Elbehairi, S. (2021). Synthesis and Antiproliferative Ativity of 2,4-Bis(indol-3-yl)pyrrole Derivatives: Marine Nortopsentin Analogs. EKB Journal Management System, 64(8), 4697-4706. doi: 10.21608/ejchem.2021.84060.4117
Mohamed Rdwan; Osama alrugaie; Waleed Al Abdulmonem; Mohammad Alfaifi; Serag Eldin Elbehairi. "Synthesis and Antiproliferative Ativity of 2,4-Bis(indol-3-yl)pyrrole Derivatives: Marine Nortopsentin Analogs". EKB Journal Management System, 64, 8, 2021, 4697-4706. doi: 10.21608/ejchem.2021.84060.4117
Rdwan, M., alrugaie, O., Al Abdulmonem, W., Alfaifi, M., Elbehairi, S. (2021). 'Synthesis and Antiproliferative Ativity of 2,4-Bis(indol-3-yl)pyrrole Derivatives: Marine Nortopsentin Analogs', EKB Journal Management System, 64(8), pp. 4697-4706. doi: 10.21608/ejchem.2021.84060.4117
Rdwan, M., alrugaie, O., Al Abdulmonem, W., Alfaifi, M., Elbehairi, S. Synthesis and Antiproliferative Ativity of 2,4-Bis(indol-3-yl)pyrrole Derivatives: Marine Nortopsentin Analogs. EKB Journal Management System, 2021; 64(8): 4697-4706. doi: 10.21608/ejchem.2021.84060.4117

Synthesis and Antiproliferative Ativity of 2,4-Bis(indol-3-yl)pyrrole Derivatives: Marine Nortopsentin Analogs

Egyptian Journal of Chemistry
Article 67, Volume 64, Issue 8, August 2021, Page 4697-4706  XML PDF (669.98 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.84060.4117
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Authors
Mohamed Rdwan email orcid 1; Osama alrugaie2; Waleed Al Abdulmonem3; Mohammad Alfaifi4; Serag Eldin Elbehairi5
1Department of Applied Organic Chemistry, National Research Center, Dokki 12622, Egypt
2Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Saudi Arabia
3Department of Pathology, College of Medicine, Qassim University, Buraidah, Saudi Arabia. (dr.waleedmonem@qu.edu.sa)
4King Khalid University, Faculty of Science, Biology Department, Abha 9004, Saudi Arabia
5Cell Culture Lab, Egyptian Organization for Biological Products and Vaccines (VACSERA Holding Company), 51 Wezaret El-Zeraa St., Agouza, Giza, Egypt
Abstract
Abstract
In this study, a series of nortopsentin analogs (2,4-bis(indol-3-yl)pyrrole derivatives) were designed, synthesized, and tested for their in vitro cytotoxic activity against three cell lines: human prostate adenocarcinoma (PC-3), human ovary adenocarcinoma (SKOV3), and human Dukes' type B colorectal adenocarcinoma (LS-174T). Compounds 5a, 5e, 5h, 5j, and 5k had stronger antiproliferative activity against SKOV3, compound 5h and 5b against LS-174T, and compound 5e against PC-3 than the known doxorubicin drug. As a result, this work provides the framework for further research into 2,4-bis(indol-3-yl)pyrrole derivatives as antiproliferative drugs.
Keywords
Indole; bisindole; nortopsentin; pyrrole; antiproliferative
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