Preparation, Characterization and Anticancer Activity of Chitosan Prepared from the American Cockroach, Periplaneta americana | ||||
| Egyptian Academic Journal of Biological Sciences. A, Entomology | ||||
| Article 10, Volume 14, Issue 2, June 2021, Page 163-171 PDF (710.46 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsa.2021.185450 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Mahmoud T. Mahboub1; Mostafa I. Hassan1; Ahmed S. Bream1; Aly F. Mohamed2; Mohammad R. K. Abdel-Samad3 | ||||
| 1Department of Zoology and Entomology, Faculty of Science, Al-Azhar University, Cairo, Egypt | ||||
| 2Research and Development Sector, VACSERA, Giza, Egypt | ||||
| 3Department of Zoology and Entomology, Faculty of Science, Al-Azhar University, Cairo, Egypt - Al-Azhar Technology Incubator, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| The exoskeleton of a cockroach plays a major role in protecting it from pathogenic microbes. It is well known that the main component of the exoskeleton is the chitin which is considered the source of chitosan. This study aimed at investigating the anticancer activity of chitosan prepared from the American cockroach. Chitosan was prepared and characterized with solubility in 1% acetic acid and Fourier transform infrared spectroscopy (FT-IR) analysis. The cytotoxicity of chitosan was investigated against Hepatoblastoma (HepG2) and Breast cancer (MCF7) cell lines by the MTT assay. The cytotoxicity has a positive relationship with the chitosan concentration. The half-maximal growth inhibitory concentrations (IC50) were 329 and 195 µg/ml with HepG2 and MCF7, respectively. Therefore, Chitosan may be a potential natural compound for the treatment of human hepatoblastoma (HepG2) and breast cancer (MCF7). | ||||
| Keywords | ||||
| Chitosan; Anticancer; Liver cancer; Breast cancer; American cockroach | ||||
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