Role of Visual Field Testing and OCT in Evaluation of Brimonidine as a Neuroprotector in Primary Open Angle Glaucoma
Nassar, M., Khairy, H., El Gohary, S., Deif, A. (2021). Role of Visual Field Testing and OCT in Evaluation of Brimonidine as a Neuroprotector in Primary Open Angle Glaucoma. EKB Journal Management System, 84(1), 2486-2494. doi: 10.21608/ejhm.2021.185508
Moustafa Kamal Nassar; Hany Ahmed Khairy; Sameh Mohamed El Gohary; Ahmed Mohamed Fawzy Deif. "Role of Visual Field Testing and OCT in Evaluation of Brimonidine as a Neuroprotector in Primary Open Angle Glaucoma". EKB Journal Management System, 84, 1, 2021, 2486-2494. doi: 10.21608/ejhm.2021.185508
Nassar, M., Khairy, H., El Gohary, S., Deif, A. (2021). 'Role of Visual Field Testing and OCT in Evaluation of Brimonidine as a Neuroprotector in Primary Open Angle Glaucoma', EKB Journal Management System, 84(1), pp. 2486-2494. doi: 10.21608/ejhm.2021.185508
Nassar, M., Khairy, H., El Gohary, S., Deif, A. Role of Visual Field Testing and OCT in Evaluation of Brimonidine as a Neuroprotector in Primary Open Angle Glaucoma. EKB Journal Management System, 2021; 84(1): 2486-2494. doi: 10.21608/ejhm.2021.185508

Role of Visual Field Testing and OCT in Evaluation of Brimonidine as a Neuroprotector in Primary Open Angle Glaucoma

The Egyptian Journal of Hospital Medicine
Article 137, Volume 84, Issue 1, July 2021, Page 2486-2494  XML PDF (318.25 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2021.185508
View on SCiNiTO View on SCiNiTO
Authors
Moustafa Kamal Nassar; Hany Ahmed Khairy; Sameh Mohamed El Gohary; Ahmed Mohamed Fawzy Deif
Abstract
Background: Glaucoma is the leading cause of global irreversible blindness optic neuropathy and retinal ganglion cell (RGC) death are the hallmarks of glaucoma. If intraocular pressure (IOP) is held within “normal” ranges, the disease process and RGC death can still progress in some patients. Neuroprotective therapies for glaucoma should aim to halt RGC loss thus preventing further structural and functional damage of the optic nerve
Objective: The aim of the current work was to study the ability of visual field testing and optical coherence tomography to reveal the neuroprotective role of brimonidine.
Patients and Methods: This prospective randomized controlled trial study included a total of 98 eyes from 50 patients affected by primary open-angle glaucoma (POAG). They were recruited from a larger population of 70 POAG patients, attending at Menofiya University Hospitals.
Results: The use of visual field-testing parameters have revealed that brimonidine had insignificantly halted glaucoma progression: MD (-0.1115 dB and -.2465 dB), VFI (-0.5882 and-1.1471) and PSD (0.1729 and 0.1894). On the other hand, some OCT parameters: average RNFL thickness (-0.7273 u and-2.2121 u), inferior RNFL thickness (-0.735 u and -1.559 u), superior RNFL thickness (-0.6364u and -1.4848 u), rim area (-0.0162 mm2 and-0.0797 mm2), average cup disc ratio (-0.01765 and 0.01824) and vertical cup disc ratio (-0.0167 and 0.0321) for study and control groups respectively, gave promising neuroprotective results for brimonidine.
Conclusion: It could be concluded that the use of visual field-testing parameters (MD, VFI and PSD) has revealed that brimonidine had insignificantly halted glaucoma progression.
Keywords
Brimonidine; Primary open angle glaucoma; Neuroprotec
Statistics
Article View: 183
PDF Download: 314