Antiurolithiatic effect of Cymbopogon Proximus, Alhagi Maurorum, on Sulfadimidine induced urolithiasis in male New Zealand rabbits | ||||
| Mansoura Veterinary Medical Journal | ||||
| Article 19, Volume 20, Issue 1, March 2019, Page 14-21 PDF (1.38 MB) | ||||
| Document Type: Original Articles | ||||
| DOI: 10.21608/mvmj.2019.01.107 | ||||
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| Authors | ||||
| Sameh El-Nabtity* ; Sohair Abdllatief; Al-Sayed Al-Attar; Selwan Taha | ||||
| Departments of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| present study aimed to investigate the prophylactic effect of Cymbopogon proximus and Alhagi maurorum on Sulfadimidine induced urolithiasis in rabbits . Thirty New Zealand male rabbits were allocated into six equal groups( each of five): Group(1) was used as a negative control. Group(2) were administered sulfadimidine (200mg/kg) by intramuscular injection.Groups(3) and (4) were administered sulfadimidine(200mg/kg) by intramuscular injection and 330mg/kg of Cymbopogon proximus alcoholic and aqueous extracts respectively orally.Groups(5) and (6) were administered sulfadimidine(200mg/kg) by intramuscular injection and 400mg/kg of Alhagi maurorum alcoholic and aqueous extracts respectively orally. The period of experiment was 10 days . Blood and urine samples were collected from rabbits on the 10th day. The results recorded a significant decrease in serum creatinine, urea, uric acid and crystalluria in Cymbopogon proximus and Alhagi maurorum groups compared to sulfadimidine treated group.We conclude that Cymbopogon proximus and Alhagi maurorum have a nephroprotective and antiurolithiatic effects against sulfadimidine induced crystalluria. | ||||
| Keywords | ||||
| Sulfadimidine; Cymbopogon proximus; Alhagi maurorum; Crystalluria; rabbit | ||||
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