URINARY LIVER TYPE FATTY ACID BINDING PROTIEN AND PLASMA CYSTATIN C PREDICT ACUTE KIDNEY INJURY OUTCOMES IN CRITICALLY ILL PATIENTS
Attia El-Farahati, M., Harash, E., Alnahal, A., Fouad, M., Ibrahim, M., Abdel-Wehab, L. (2023). URINARY LIVER TYPE FATTY ACID BINDING PROTIEN AND PLASMA CYSTATIN C PREDICT ACUTE KIDNEY INJURY OUTCOMES IN CRITICALLY ILL PATIENTS. EKB Journal Management System, 29(3), 920-927. doi: 10.21608/zumj.2021.81066.2266
Mohammed Attia El-Farahati; Essam Lotfy Harash; Alsayed Alnahal; Mohamed Fouad; Medhat Ibrahim; Lamiaa Abdel-Wehab. "URINARY LIVER TYPE FATTY ACID BINDING PROTIEN AND PLASMA CYSTATIN C PREDICT ACUTE KIDNEY INJURY OUTCOMES IN CRITICALLY ILL PATIENTS". EKB Journal Management System, 29, 3, 2023, 920-927. doi: 10.21608/zumj.2021.81066.2266
Attia El-Farahati, M., Harash, E., Alnahal, A., Fouad, M., Ibrahim, M., Abdel-Wehab, L. (2023). 'URINARY LIVER TYPE FATTY ACID BINDING PROTIEN AND PLASMA CYSTATIN C PREDICT ACUTE KIDNEY INJURY OUTCOMES IN CRITICALLY ILL PATIENTS', EKB Journal Management System, 29(3), pp. 920-927. doi: 10.21608/zumj.2021.81066.2266
Attia El-Farahati, M., Harash, E., Alnahal, A., Fouad, M., Ibrahim, M., Abdel-Wehab, L. URINARY LIVER TYPE FATTY ACID BINDING PROTIEN AND PLASMA CYSTATIN C PREDICT ACUTE KIDNEY INJURY OUTCOMES IN CRITICALLY ILL PATIENTS. EKB Journal Management System, 2023; 29(3): 920-927. doi: 10.21608/zumj.2021.81066.2266

URINARY LIVER TYPE FATTY ACID BINDING PROTIEN AND PLASMA CYSTATIN C PREDICT ACUTE KIDNEY INJURY OUTCOMES IN CRITICALLY ILL PATIENTS

Zagazig University Medical Journal
Article 23, Volume 29, Issue 3, May and June 2023, Page 920-927  XML PDF (442.84 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.81066.2266
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Authors
Mohammed Attia El-Farahati email orcid 1; Essam Lotfy Harash2; Alsayed Alnahalorcid 3; Mohamed Fouadorcid 3; Medhat Ibrahim4; Lamiaa Abdel-Wehab5
1Internal Medicine, Faculty of medicine, zagazig University, Egypt
2Faculty of medicine, zagazig University
3Internal Medicine, Zagazig University
4Internal Medicine, Faculty of medicine, zagazig University
5Department of Clinical Pathology, Faculty of Medicine - Zagazig University, Egypt
Abstract
Acute kidney injury (AKI) is a devastating problem that is commonly associated with worse clinical outcomes in critically ill patients. AKI is an independent risk factor for chronic kidney disease, prolonged hospital stay and increased mortalities. several novel biomarkers have been validated for the early diagnosis of AKI. Some of them recently proved to be more effective than those usually used. Liver-type fatty acid-binding protein (L-FABP), a 14kDa protein in the cytoplasm of human renal proximal tubules and bind free fatty acids in response to renal injury. several studies showed that L-FABP is a promising biomarker of several kidney disease. Cystatin C (Cys-C), a low molecular weight protein produced by all nucleated cells of the body, is filtered through glomeruli, and reabsorbed completely through the proximal renal tubules. Also, plasma cystatin C is independent of several factors such as muscle mass, age and gender. Cys-C is investigated to be a good functional biomarker for diagnosis of AKI.
Keywords
Liver Fatty Acid Binding Protein; Cystatin C; Creatinine; Critically Ill; Acute Kidney Injury
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