Correlation between Iron Status and Simple Febrile Seizures in Children | ||||
| International Journal of Medical Arts | ||||
| Article 30, Volume 3, Issue 3, July 2021, Page 1714-1718 PDF (1.44 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2021.79064.1320 | ||||
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| Authors | ||||
Marwa Elkafafy  1; Magdy Mohamed Ashmawy Sakr2; Mohamed Ibrahim Elsamanoudy 2; hesham samir abd al-samee 3
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| 1Department of Pediatrics, EL-Raml Pediatric Hospital, Ministry of Health, Egypt | ||||
| 2Department of Pediatrics, Damietta Faculty of Medicine, AL-Azhar University, Egypt | ||||
| 3Department of Clinical Pathology, Damietta Faculty of Medicine, AL-Azhar University, Egypt | ||||
| Abstract | ||||
| Background: Febrile seizures are non-epileptic types of seizure that occur frequently during early childhood. Multiple factors are implicated in the pathogenesis of these types of seizures. Iron deficiency might play as an etiological or, at least, augmenting factor in the development of febrile seizures. Objective: To study iron status among children with simple febrile seizures, and to estimate the prevalence of iron deficiency between them. Patients and methods: A case-control study included 100 febrile children aged 6 months to 60 months, and were ascribed to 2 groups; 50 children with simple febrile seizures [case group], and 50 children who had febrile disease without occurrence of seizures [control group]. Venous samples were obtained for the analysis of complete blood count, and iron indices [serum ferritin, serum iron and total iron binding capacity]. Results: The peak temperature was significantly elevated among the case group [P=0.03]. Regarding iron profile, compared to controls, the case group had significantly lower iron [54.24±16.04 vs. 62.6±16.02; P=0.011], and lower ferritin [37.612±19.85 vs. 80.624±31.57; P <0.001]. Correlation analysis revealed a significant negative correlation between serum ferritin and frequency of febrile seizures [P=0.025] Conclusions: Iron deficiency and iron deficiency anemia were more common among children with simple febrile seizures, and they were associated with increase in the duration and frequency of seizures. Special attention should be paid for the assessment of iron status among children with febrile seizures. | ||||
| Keywords | ||||
| Fever; Seizures; Iron; Anemia; Febrile seizures | ||||
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