Effects of Occupational Exposure to the Hepatotoxic Chemical Vinyl Chloride Monomer on Reduced Glutathione and its Related Enzymes | ||||
| Journal of High Institute of Public Health | ||||
| Article 3, Volume 34, Issue 3, July 2004, Page 517-528 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jhiph.2004.186159 | ||||
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| Authors | ||||
| Awatef M. El-Sharkawi1; Gamal El-Den A. Bader2 | ||||
| 1Applied Medical Chemistry Department, Medical Research Institute, Alexandria University, Egypt | ||||
| 2Internal Medicine Department, Medical Research Institute, Alexandria University, Egypt | ||||
| Abstract | ||||
| The effect of vinyl chloride monomer exposure on the liver of workers was studied by measuring the level of blood glutathione, glutathione-S-transferase, ỿ-glutamyl transferase, routine liver function enzymes, and alpha feto protein in the sera of eorkers. The results showed a significant decrease in the level of blood glutathione, a significant increase in the enzyme activity level of glutathione-S-transferase, and a significant increase also in the ỿ-glutamyl transferase. On the other hand, the ratio of ALT/AST= 1.07 which indicated the insignificant result of these enzymes. Of 21 workers, 14 had fatty liver infiltration, 8 of whom were also suffering from liver enlargement. Four workers had liver enlargement without fatty infiltration. The study highlights the need for vigilance in environmental monitoring and medical surveillance of workers exposed to this chemical. | ||||
| Keywords | ||||
| vinylchloride; glutathione; glutathione-S-transferase; ỿ-glutamyl transferase; routine liver function enzymes; alpha feto protein | ||||
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