SYNTHESIS OF SOME NEW BENZIMIDAZOLE DERIVATIVES WITH POTENTIAL ANTIMICROBIAL ACTIVITY | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 27, Volume 4, Issue 2, December 1995, Page 198-203 PDF (2.6 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.1995.186294 | ||||
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| Author | ||||
Nabaweya Sharaf El-Din 
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| Departments of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tanta, Tanta, Egypt | ||||
| Abstract | ||||
| A series of 2-aminomethylbenzimidazole (1) and 2-benzimidazolone (II) derivatives were synthesized. Imidazo-and Pyrazino-derivatives (IIIa-g) were obtained from the reaction of compound (1) with acetic anhydride, glycine, carbon disulfide, ioroform, dibromoethane, phenacylbromide or diethyloxalate. Condensation of compound (1), acid hydrazide (VII) or compound II with some aldehydes or some amines, the Schiff's bases (IVa-b), (VIIIA,b) or (Va-c) respectively were produced. In addition, compound (II) was reacted with acetic anhydride to afford the diacetyl derivatives (IX) which was condensed with hydrazine, urea or thiourea to yield a triazolo-or triazino-derivatives X and XIa,b respectively. The prepared compounds were tested against some fungi and bacteria. Some of these compounds were found to have antimicrobial activity. | ||||
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