SYNTHESIS, CIRCUILAR DICHROISM AND BIOLOGICAL ACTIVITIES OF BRADYKININ AND SOME ANALOGS
Abdel-Rahman, S. (1995). SYNTHESIS, CIRCUILAR DICHROISM AND BIOLOGICAL ACTIVITIES OF BRADYKININ AND SOME ANALOGS. EKB Journal Management System, 4(1), 18-24. doi: 10.21608/zjps.1995.186310
Somaya Abdel-Rahman. "SYNTHESIS, CIRCUILAR DICHROISM AND BIOLOGICAL ACTIVITIES OF BRADYKININ AND SOME ANALOGS". EKB Journal Management System, 4, 1, 1995, 18-24. doi: 10.21608/zjps.1995.186310
Abdel-Rahman, S. (1995). 'SYNTHESIS, CIRCUILAR DICHROISM AND BIOLOGICAL ACTIVITIES OF BRADYKININ AND SOME ANALOGS', EKB Journal Management System, 4(1), pp. 18-24. doi: 10.21608/zjps.1995.186310
Abdel-Rahman, S. SYNTHESIS, CIRCUILAR DICHROISM AND BIOLOGICAL ACTIVITIES OF BRADYKININ AND SOME ANALOGS. EKB Journal Management System, 1995; 4(1): 18-24. doi: 10.21608/zjps.1995.186310

SYNTHESIS, CIRCUILAR DICHROISM AND BIOLOGICAL ACTIVITIES OF BRADYKININ AND SOME ANALOGS

Zagazig Journal of Pharmaceutical Sciences
Article 3, Volume 4, Issue 1, June 1995, Page 18-24  XML PDF (4.49 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1995.186310
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Author
Somaya Abdel-Rahman email
Chemistry Dept., Faculty of Science, Zagazig University, Egypt.
Abstract
Bradykinin (BK) and three of its analogs, (DAla)7 BK, (Gly)7 BK and (Pro)6 BK were synthesized by the continuous flow method. Polystyrene-polyethylene glycol graft copolymer was employed as modified polymeric support. The effect of the replacement of Pro7 by DAla, Gly and Ser6 by Pro on the 3--->1 intramolecular hydrogen bond present in BK chain, between the carbonyl oxygen of Ser6 and the amide proton of Phe8 bridging Pro7, was investigated. Although there are remarkable changes in the CD spectral features of these analogs compared to that of BK, they exhibited comparable biological activities.
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