SYNTHESIS OF SOME PYRIMIDO-[4', 5' : 4,5]-PYRIMIDO-[ 1,6-a ]INDOLE OF POTENTIAL ANTIINFLAMMATORY AND ANTIPYRETIC ACTIVITIES | ||||
Zagazig Journal of Pharmaceutical Sciences | ||||
Article 7, Volume 4, Issue 1, June 1995, Page 36-42 PDF (3.12 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjps.1995.186326 | ||||
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Authors | ||||
Mohamed Ebeid 1; Sayed Lashine2; Sobhy El-Adl3; Mansour Abou-Kull4 | ||||
1Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt | ||||
2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt | ||||
3Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt | ||||
4Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt | ||||
Abstract | ||||
The synthesis of 12,12a-dihydropyrimido-[4',5' : 4,5]-pyrimido-[1,6-a]-indole-1,6[ 2H, 5H]-dione is described. Treatment of enaminonitriles I with chloroacetyl chloride afforded the tetracyclic compounds II. In contrast compound I with nuorophenyl group at position 2 gave N-chloroacetylamino derivatives III which underwent cyclization either by acid or base. Preliminary Pharmacological screening of some compounds showed significant antiinflammatory and antipyretic activities. | ||||
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