SOME BIOCHEMICAL STUDIES ON THE RODENTICIDE ZINC PHOSPHIDE | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 15, Volume 4, Issue 1, June 1995, Page 109-116 PDF (3.84 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.1995.186365 | ||||
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| Authors | ||||
Mohamed Abdel-Halim  ; Aziza El-Shafey; Moshera Selem
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| Department of Zoology, Faculty of Science, Zagazig University (Benha Branch), Egypt. | ||||
| Abstract | ||||
| The present investigation is an attempt to study the hazardous effects associated with the use of the rodenticide zinc phosphide (Zn3,P2) in the albino rats as a useful model for man. The LD50 of Zn3, P2 205 mg/kg b.wt. caused a significant decrease (P < 0.05) of serum glucose and a highly significant decreases (P < 0.01) in liver and muscle glycogen. Total lipid contents, total protein contents, Aspartate amino transferase (AST) and Alanine aminotransferase (ALT) activities showed a great alterations. The sublethal dose of Zn3 P2 (102.5 mg/kd b.wt.) elicited a great deteriorations in all the above mentioned parameters in serum, liver and muscles. These deteriorating effects of Zn3 P2 may extend to the sixth day after its administration. Thus, the toxic effect of the rodenticide is not limited to the target animals, so it should be empolyed with a great care in rodent control. | ||||
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