ANTICHOLINE ESTRASE ACTIVITY OF ENROFLOXACIN IN CATFISH
Abdel-Alim, A., Abdel Fadil, H., Said, A., Amer, M., El-Dawy, K. (1995). ANTICHOLINE ESTRASE ACTIVITY OF ENROFLOXACIN IN CATFISH. EKB Journal Management System, 4(1), 1-6. doi: 10.21608/zjps.1995.186384
Abdel -Alim Abdel-Alim; Hosny Abdel Fadil; Ahmed A. Said; Magdy Amer; Khalifa El-Dawy. "ANTICHOLINE ESTRASE ACTIVITY OF ENROFLOXACIN IN CATFISH". EKB Journal Management System, 4, 1, 1995, 1-6. doi: 10.21608/zjps.1995.186384
Abdel-Alim, A., Abdel Fadil, H., Said, A., Amer, M., El-Dawy, K. (1995). 'ANTICHOLINE ESTRASE ACTIVITY OF ENROFLOXACIN IN CATFISH', EKB Journal Management System, 4(1), pp. 1-6. doi: 10.21608/zjps.1995.186384
Abdel-Alim, A., Abdel Fadil, H., Said, A., Amer, M., El-Dawy, K. ANTICHOLINE ESTRASE ACTIVITY OF ENROFLOXACIN IN CATFISH. EKB Journal Management System, 1995; 4(1): 1-6. doi: 10.21608/zjps.1995.186384

ANTICHOLINE ESTRASE ACTIVITY OF ENROFLOXACIN IN CATFISH

Zagazig Journal of Pharmaceutical Sciences
Article 1, Volume 4, Issue 1, June 1995, Page 1-6  XML PDF (4.21 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1995.186384
View on SCiNiTO View on SCiNiTO
Authors
Abdel -Alim Abdel-Alim email 1; Hosny Abdel Fadil2; Ahmed A. Said3; Magdy Amer4; Khalifa El-Dawy5
1Department of Pharmacology Faculty of Veterinary Medicine, Zagazig University, Egypt
2Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Egypt.
3Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, and Suez Canal University,
4Department of Pharmacology, Faculty of Veterinary Medicine, University of Mansoura, Egypt.
5Biochemistry Dept., Faculty of Vet. Med., Zagazig University, Egypt
Abstract
Enrofloxacin evoked a dose-dependant stimulatory effect on the isolated intestinal smooth muscles of catfish. The drug potentiated the effect of acetylcholine on the isolated catfish epiaxial muscle. Moreover, enrofloxacin exerted a negative inotropic and chronotropic activities on the isolated catfish heart. Furthermore, the drug significantly increased the acetylcholine concentrations in the isolated intestinal preparations of catfish. The previous responses were proved to be due to an anticholine-estrase activity of the drug. Catfish treated with enrofloxacin elicited a significant decrease in serum calcium and alpha2, globulins levels with a significant increase in phosphorus, triiodothyronine and thyroxine levels. In conclusion. enrofloxacin displayed an anticholine-estrase activity and evoked a significant decrease in serum calcium, alpha2, globulin with elevated phosphorus, tri-iodothyronine and thyroxine levels in catfish.
Statistics
Article View: 52
PDF Download: 81