USE OF CERTAIN METAL IONS FOR THE DETERMINATION OF INDOMETHACIN
Ayad, M., Saleh, H., El-Adl, S., El-Kousy, N., Taha, E. (1994). USE OF CERTAIN METAL IONS FOR THE DETERMINATION OF INDOMETHACIN. EKB Journal Management System, 3(2), 32-39. doi: 10.21608/zjps.1994.186441
Magda Ayad; Hanaa Saleh; Sobhy El-Adl; Nagla El-Kousy; Elham Taha. "USE OF CERTAIN METAL IONS FOR THE DETERMINATION OF INDOMETHACIN". EKB Journal Management System, 3, 2, 1994, 32-39. doi: 10.21608/zjps.1994.186441
Ayad, M., Saleh, H., El-Adl, S., El-Kousy, N., Taha, E. (1994). 'USE OF CERTAIN METAL IONS FOR THE DETERMINATION OF INDOMETHACIN', EKB Journal Management System, 3(2), pp. 32-39. doi: 10.21608/zjps.1994.186441
Ayad, M., Saleh, H., El-Adl, S., El-Kousy, N., Taha, E. USE OF CERTAIN METAL IONS FOR THE DETERMINATION OF INDOMETHACIN. EKB Journal Management System, 1994; 3(2): 32-39. doi: 10.21608/zjps.1994.186441

USE OF CERTAIN METAL IONS FOR THE DETERMINATION OF INDOMETHACIN

Zagazig Journal of Pharmaceutical Sciences
Article 4, Volume 3, Issue 2, December 1994, Page 32-39  XML PDF (3.09 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1994.186441
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Authors
Magda Ayad email 1; Hanaa Saleh2; Sobhy El-Adl3; Nagla El-Kousy4; Elham Taha5
1Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University. Zagazig. Egypt.
2Department of Analytical Chemistry, Faculty of Pharmacy, University of Zagazig, Egypt.
3Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt
4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Zagazig, Egypt.
5National Organization for Drug Control and Research, Giza, Egypt.
Abstract
A simple and accurate method was described for the quantitative determination of indomethacin using Ag+ and Cu2+ ions. Indomethacin was precipitated from its neutral alcoholic solution by standard solutions of silver nitrate and copper acetate followed by determining the resulted slats using atomic absorption spectroscopy and colorimetric techniques. The optimum conditions for silver and copper indomethacin slat formations have been carefully studied. The molar ratio of the reactants in the case of copper was ascertained by atomic absorption spectroscopy and by formation of copper sodium diethyldithiocarbamate and was found to be 2:1 (indomethacin: cu+2). Both of the developed methods were compared with the previous official methods to indicate high accuracy (t-test) and reproducibility (f-test).
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