SYNTHESIS OF SOME PYRIMIDO-[1,6-a]- INDOLE OF POTENTIAL PHARMACOLOGICAL INTEREST | ||||
Zagazig Journal of Pharmaceutical Sciences | ||||
Article 5, Volume 3, Issue 2, December 1994, Page 40-48 PDF (3.76 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjps.1994.186442 | ||||
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Authors | ||||
Mohamed Ebeid 1; Sayed Lashine2; Sobhy El-Adl3; Mansour Abou-Kull4 | ||||
1Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt | ||||
2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt | ||||
3Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt | ||||
4Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt | ||||
Abstract | ||||
The synthesis of some pyrimido-[1,6-a]- indole derivatives is described. Addition of dicyanomethylideneindoline (I) to various isocyanates gave 2-alkyl-3-imino-1-oxo-1,2,3,5- tetrahydropyrimido-[1,6-a]- indole-4-carbonitrile lla-h. The corresponding enaminonitriles Illa-h were obtained from II by reduction with sodium borohydride. Compounds IV-VIl were also obtained. Preliminary pharmacological screening revealed antipyretic, antiinflammatory and analgesic activities. | ||||
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